The human microbiome harbors many unidentified species. By large-scale metagenomic assembly of samples from diverse populations, we uncovered >150,000 microbial genomes that are recapitulated in 4,930 species. Many species (77%) were never described before, increase the mappability of metagenomes, and expand our understanding of global body-wide human microbiomes.
Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle / Pasolli, E., Asnicar, F., Manara, S., Zolfo, M., Karcher, N., Armanini, F., Beghini, F., Manghi, P., Tett, A., Ghensi, P., Collado, M.C., Rice, B.L., Dulong, C., Morgan, X.C., Golden, C.D., Quince, C., Huttenhower, C., Segata, N.. - In: CELL. - ISSN 0092-8674. - 176:3(2019), pp. 649-662. [10.1016/j.cell.2019.01.001]
Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle
Pasolli, Edoardo;Asnicar, Francesco;Manara, Serena;Zolfo, Moreno;Karcher, Nicolai;Armanini, Federica;Beghini, Francesco;Manghi, Paolo;Tett, Adrian;Ghensi, Paolo;Segata, Nicola
2019-01-01
Abstract
The human microbiome harbors many unidentified species. By large-scale metagenomic assembly of samples from diverse populations, we uncovered >150,000 microbial genomes that are recapitulated in 4,930 species. Many species (77%) were never described before, increase the mappability of metagenomes, and expand our understanding of global body-wide human microbiomes.| File | Dimensione | Formato | |
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