Staphylococcus aureus is an opportunistic pathogen and a leading cause of nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics to date, and the World Health Organization defined it as a high-priority pathogen for research and development of new antibiotics. A deeper understanding of the genetic variability of S. aureus in clinical settings would lead to a better comprehension of its pathogenic potential and improved strategies to contrast its virulence and resistance. However, the number of comprehensive studies addressing clinical cohorts of S. aureus infections by simultaneously looking at the epidemiology, phylogenetic reconstruction, genomic characterisation, and transmission pathways of infective clones is currently low, thus limiting global surveillance and epidemiological monitoring.

Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital / Manara, Serena; Pasolli, Edoardo; Dolce, Daniela; Ravenni, Novella; Campana, Silvia; Armanini, Federica; Asnicar, Francesco; Mengoni, Alessio; Galli, Luisa; Montagnani, Carlotta; Venturini, Elisabetta; Rota-Stabelli, Omar; Grandi, Guido; Taccetti, Giovanni; Segata, Nicola. - In: GENOME MEDICINE. - ISSN 1756-994X. - 10:1(2018), p. 82. [10.1186/s13073-018-0593-7]

Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital

Manara, Serena;Pasolli, Edoardo;Armanini, Federica;Asnicar, Francesco;Rota-Stabelli, Omar;Grandi, Guido;Segata, Nicola
2018-01-01

Abstract

Staphylococcus aureus is an opportunistic pathogen and a leading cause of nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics to date, and the World Health Organization defined it as a high-priority pathogen for research and development of new antibiotics. A deeper understanding of the genetic variability of S. aureus in clinical settings would lead to a better comprehension of its pathogenic potential and improved strategies to contrast its virulence and resistance. However, the number of comprehensive studies addressing clinical cohorts of S. aureus infections by simultaneously looking at the epidemiology, phylogenetic reconstruction, genomic characterisation, and transmission pathways of infective clones is currently low, thus limiting global surveillance and epidemiological monitoring.
2018
1
Manara, Serena; Pasolli, Edoardo; Dolce, Daniela; Ravenni, Novella; Campana, Silvia; Armanini, Federica; Asnicar, Francesco; Mengoni, Alessio; Galli, Luisa; Montagnani, Carlotta; Venturini, Elisabetta; Rota-Stabelli, Omar; Grandi, Guido; Taccetti, Giovanni; Segata, Nicola
Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital / Manara, Serena; Pasolli, Edoardo; Dolce, Daniela; Ravenni, Novella; Campana, Silvia; Armanini, Federica; Asnicar, Francesco; Mengoni, Alessio; Galli, Luisa; Montagnani, Carlotta; Venturini, Elisabetta; Rota-Stabelli, Omar; Grandi, Guido; Taccetti, Giovanni; Segata, Nicola. - In: GENOME MEDICINE. - ISSN 1756-994X. - 10:1(2018), p. 82. [10.1186/s13073-018-0593-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/220152
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