IRIS
Biasini, Emiliano
 Distribuzione geografica
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Continente #
NA - Nord America 3.928
EU - Europa 969
AS - Asia 749
SA - Sud America 64
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 3
OC - Oceania 2
Totale 5.721
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Nazione #
US - Stati Uniti d'America 3.914
SG - Singapore 474
RU - Federazione Russa 272
IT - Italia 264
CN - Cina 150
FI - Finlandia 116
SE - Svezia 89
GB - Regno Unito 75
DE - Germania 70
BR - Brasile 59
JO - Giordania 42
VN - Vietnam 24
NL - Olanda 23
BG - Bulgaria 20
TR - Turchia 16
ID - Indonesia 15
CA - Canada 11
UA - Ucraina 9
HK - Hong Kong 5
IN - India 5
AT - Austria 4
BE - Belgio 4
EU - Europa 4
IE - Irlanda 4
AZ - Azerbaigian 3
JP - Giappone 3
LT - Lituania 3
MA - Marocco 3
MX - Messico 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AU - Australia 2
BY - Bielorussia 2
CZ - Repubblica Ceca 2
FR - Francia 2
GR - Grecia 2
IQ - Iraq 2
LU - Lussemburgo 2
PK - Pakistan 2
VE - Venezuela 2
AE - Emirati Arabi Uniti 1
BO - Bolivia 1
DK - Danimarca 1
EC - Ecuador 1
ES - Italia 1
HU - Ungheria 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LV - Lettonia 1
PH - Filippine 1
PL - Polonia 1
PY - Paraguay 1
QA - Qatar 1
RO - Romania 1
SA - Arabia Saudita 1
UZ - Uzbekistan 1
Totale 5.721
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Città #
Fairfield 562
Chandler 505
Ashburn 277
Woodbridge 237
Seattle 230
San Mateo 222
Singapore 218
Houston 205
Cambridge 188
Wilmington 174
Ann Arbor 163
Santa Clara 145
Moscow 125
Columbus 123
Princeton 113
Helsinki 80
Jacksonville 69
The Dalles 54
Trento 48
Beijing 46
San Diego 38
Dearborn 34
New York 33
Como 26
North Bergen 24
San Paolo di Civitate 22
Boardman 20
London 20
Fremont 19
Sofia 19
Dong Ket 14
Jakarta 14
Izmir 13
Munich 13
Norwalk 12
Falkenstein 11
Perugia 11
Council Bluffs 10
Tolentino 10
Nanjing 9
Rome 8
Toronto 8
Bassano del Grappa 7
Des Moines 7
Milan 7
Shanghai 7
Washington 7
Bonndorf 5
Costa Mesa 5
Hong Kong 5
Nuremberg 5
São Paulo 5
Altamura 4
Bremen 4
Brussels 4
Dallas 4
Dublin 4
Los Angeles 4
Naples 4
Verona 4
Vienna 4
Amsterdam 3
Augusta 3
Baku 3
Berlin 3
Bologna 3
Casalecchio di Reno 3
Caserta 3
Frankfurt am Main 3
Guangzhou 3
Guarulhos 3
Kilburn 3
Ottawa 3
Padova 3
Andover 2
Aracaju 2
Athens 2
Augsburg 2
Belo Horizonte 2
Bitburg 2
Caruaru 2
Catania 2
Cernusco sul Naviglio 2
Chengdu 2
Chicago 2
Chiswick 2
Divinópolis 2
Elk Grove Village 2
Foligno 2
Groningen 2
Hangzhou 2
Hefei 2
Hounslow 2
Isesaki 2
Jinan 2
Kunming 2
Leipzig 2
Messina 2
Mexico City 2
Minsk 2
Totale 4.359
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Nome #
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors 192
Regulation of HuR structure and function by dihydrotanshinone-I 182
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein 178
Full atomistic model of prion structure and conversion 168
A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity 141
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein 139
Pharmacological inactivation of the prion protein by targeting a folding intermediate 135
Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo 132
Acute Neurotoxicity Models of Prion Disease 126
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo 125
Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: A novel pharmacological strategy against brain injury 118
Mutant prion protein expression is associated with an alteration of the rab GDP dissociation inhibitor α (GDI)/rab11 pathway 118
The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells 118
Understanding prion structure and conversion 118
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein 114
Pharmacological Agents Targeting the Cellular Prion Protein 106
A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide 105
All-Atom Simulation of HET-s Prion Replication 104
Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface 103
The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers 102
Common therapeutic strategies for prion and Alzheimer's diseases 101
Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity 101
Decoding the function of the N-terminal tail of the cellular prion protein to inspire novel therapeutic avenues for neurodegenerative diseases 99
Ok google, how could i design therapeutics against prion diseases? 99
An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity 98
The hydrophobic core region governs mutant prion protein aggregation and intracellular retention 97
The N-terminal, polybasic region of PrP C dictates the efficiency of prion propagation by binding to PrP Sc 97
Characterization of Physical, Mechanical, and Biological Properties of SilkBridge Nerve Conduit after Enzymatic Hydrolysis 96
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity 95
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein 92
The N-terminal, polybasic region is critical for prion protein neuroprotective activity 91
The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells 90
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities 87
The cellular prion protein beyond prion diseases 87
null 86
Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases 83
Proteasome inhibition and aggregation in Parkinson's disease: A comparative study in untransfected and transfected cells 82
A designer chaperone against prion diseases 82
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation 80
Immunopurification of pathological prion protein aggregates 79
Generation, optimization and characterization of novel anti-prion compounds 79
GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice 76
Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans 76
The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases 74
Non-infectious aggregates of the prion protein react with several PrP Sc-directed antibodies 70
Modeling PrPSc Generation Through Deformed Templating 70
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia 64
Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion 63
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention 63
null 62
Targeting the cellular prion protein to treat neurodegeneration 62
Prion protein ligands as therapeutic agents for neurodegenerative disorders 61
Role of lipid rafts and GM1 in the segregation and processing of prion protein 59
Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse 53
Pliability in the m6A-Binding Region Extends Druggability of YTH Domains 50
A Method for Identifying Intermediates 50
Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency 47
Ion channels induced by the prion protein: Mediators of neurotoxicity 46
Redox regulation of cyclophilin A by glutathionylation 43
Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity 42
Identification of the zebrafish homologues of IMPG2, a retinal proteoglycan 41
Functional, pathogenic, and pharmacological roles of protein folding intermediates 40
Infectious and pathogenic forms of PrP 36
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies 33
Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of sars-cov-2 infectivity 28
Gene expression profiling in trigeminal ganglia from Cntnap2-/- and Shank3b-/- mouse models of autism spectrum disorder 27
Small molecules inducing the degradation of the cellular prion protein 17
Small moleules inducing the degradation of the cellular prion protein 14
null 11
Prion protein at the crossroads of physiology and disease 9
A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint 8
Enantiomers of the prion protein degrader SM875: Production and configurational assignment, in silico analysis and in vitro evaluation 1
Totale 5.921
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Categoria #
all - tutte 32.049
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 759
selected - selezionate 0
volume - volumi 1.026
Totale 33.834
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202069 0 0 0 0 0 0 0 0 0 0 41 28
2020/2021743 33 52 28 53 29 108 51 83 50 112 98 46
2021/2022852 52 217 7 33 8 21 35 190 35 63 99 92
2022/2023997 102 129 6 139 110 151 7 69 163 21 51 49
2023/2024421 21 52 23 20 36 86 48 38 4 14 12 67
2024/20251.455 11 15 131 285 122 171 38 81 236 344 21 0
Totale 5.921