The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, by acting as a toxicity-transducing receptor for different misfolded protein isoforms, or in some case by exerting neuroprotective effects. Interestingly, PrPC has also been reported to play unexpected functions outside the nervous system, for example by contributing to myelin homeostasis, regulating specific processes of the immune system and participating in various aspects of cancer progression. Collectively, these observations point to a much broader role for PrPC in physiological and disease processes than originally assumed. In this manuscript, we provide an overview of what is known about the role of PrPC beyond prion disorders and discuss the potential implications of targeting this protein in different diseases.

The cellular prion protein beyond prion diseases / Manni, G.; Lewis, V.; Senesi, M.; Spagnolli, G.; Fallarino, F.; Collins, S. J.; Mouillet-Richard, S.; Biasini, E.. - In: SWISS MEDICAL WEEKLY. - ISSN 1424-7860. - 150:(2020), p. w20222. [10.4414/smw.2020.20222]

The cellular prion protein beyond prion diseases

Spagnolli G.;Collins S. J.;Biasini E.
2020-01-01

Abstract

The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, by acting as a toxicity-transducing receptor for different misfolded protein isoforms, or in some case by exerting neuroprotective effects. Interestingly, PrPC has also been reported to play unexpected functions outside the nervous system, for example by contributing to myelin homeostasis, regulating specific processes of the immune system and participating in various aspects of cancer progression. Collectively, these observations point to a much broader role for PrPC in physiological and disease processes than originally assumed. In this manuscript, we provide an overview of what is known about the role of PrPC beyond prion disorders and discuss the potential implications of targeting this protein in different diseases.
2020
Manni Giorgia, Lewis Victoria, Senesi Matteo, Spagnolli Giovanni, Fallarino Francesca, Collins Steven J, Mouillet-Richard Sophiee, Biasini Emiliano
Manni, G.; Lewis, V.; Senesi, M.; Spagnolli, G.; Fallarino, F.; Collins, S. J.; Mouillet-Richard, S.; Biasini, E.
The cellular prion protein beyond prion diseases / Manni, G.; Lewis, V.; Senesi, M.; Spagnolli, G.; Fallarino, F.; Collins, S. J.; Mouillet-Richard, S.; Biasini, E.. - In: SWISS MEDICAL WEEKLY. - ISSN 1424-7860. - 150:(2020), p. w20222. [10.4414/smw.2020.20222]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/283899
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