Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrPC) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrPC as well as the antiprion agents closest to clinical application.

The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases / Astolfi, A.; Spagnolli, G.; Biasini, E.; Barreca, M. L.. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 11:11(2020), pp. 2063-2067. [10.1021/acsmedchemlett.0c00528]

The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases

Spagnolli G.;Biasini E.;
2020-01-01

Abstract

Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrPC) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrPC as well as the antiprion agents closest to clinical application.
2020
Astolfi A, Spagnolli G, Biasini E, Barreca ML.
Astolfi, A.; Spagnolli, G.; Biasini, E.; Barreca, M. L.
The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases / Astolfi, A.; Spagnolli, G.; Biasini, E.; Barreca, M. L.. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 11:11(2020), pp. 2063-2067. [10.1021/acsmedchemlett.0c00528]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/283901
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