Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.

Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer / Terrisse, Safae; Goubet, Anne-Gaelle; Ueda, Kousuke; Thomas, Andrew Maltez; Quiniou, Valentin; Thelemaque, Cassandra; Dunsmore, Garett; Clave, Emmanuel; Gamat-Huber, Melissa; Yonekura, Satoru; Ferrere, Gladys; Rauber, Conrad; Pham, Hang Phuong; Fahrner, Jean-Eudes; Pizzato, Eugenie; Ly, Pierre; Fidelle, Marine; Mazzenga, Marine; Costa Silva, Carolina Alves; Armanini, Federica; Pinto, Federica; Asnicar, Francesco; Daillère, Romain; Derosa, Lisa; Richard, Corentin; Blanchard, Pierre; Routy, Bertrand; Culine, Stéphane; Opolon, Paule; Silvin, Aymeric; Ginhoux, Florent; Toubert, Antoine; Segata, Nicola; Mcneel, Douglas G; Fizazi, Karim; Kroemer, Guido; Zitvogel, Laurence. - In: JOURNAL FOR IMMUNOTHERAPY OF CANCER. - ISSN 2051-1426. - 10:3(2022), pp. e00419101-e00419112. [10.1136/jitc-2021-004191]

Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer

Thomas, Andrew Maltez;Armanini, Federica;Pinto, Federica;Asnicar, Francesco;Segata, Nicola;
2022-01-01

Abstract

Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.
2022
3
Terrisse, Safae; Goubet, Anne-Gaelle; Ueda, Kousuke; Thomas, Andrew Maltez; Quiniou, Valentin; Thelemaque, Cassandra; Dunsmore, Garett; Clave, Emmanuel; Gamat-Huber, Melissa; Yonekura, Satoru; Ferrere, Gladys; Rauber, Conrad; Pham, Hang Phuong; Fahrner, Jean-Eudes; Pizzato, Eugenie; Ly, Pierre; Fidelle, Marine; Mazzenga, Marine; Costa Silva, Carolina Alves; Armanini, Federica; Pinto, Federica; Asnicar, Francesco; Daillère, Romain; Derosa, Lisa; Richard, Corentin; Blanchard, Pierre; Routy, Bertrand; Culine, Stéphane; Opolon, Paule; Silvin, Aymeric; Ginhoux, Florent; Toubert, Antoine; Segata, Nicola; Mcneel, Douglas G; Fizazi, Karim; Kroemer, Guido; Zitvogel, Laurence
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer / Terrisse, Safae; Goubet, Anne-Gaelle; Ueda, Kousuke; Thomas, Andrew Maltez; Quiniou, Valentin; Thelemaque, Cassandra; Dunsmore, Garett; Clave, Emmanuel; Gamat-Huber, Melissa; Yonekura, Satoru; Ferrere, Gladys; Rauber, Conrad; Pham, Hang Phuong; Fahrner, Jean-Eudes; Pizzato, Eugenie; Ly, Pierre; Fidelle, Marine; Mazzenga, Marine; Costa Silva, Carolina Alves; Armanini, Federica; Pinto, Federica; Asnicar, Francesco; Daillère, Romain; Derosa, Lisa; Richard, Corentin; Blanchard, Pierre; Routy, Bertrand; Culine, Stéphane; Opolon, Paule; Silvin, Aymeric; Ginhoux, Florent; Toubert, Antoine; Segata, Nicola; Mcneel, Douglas G; Fizazi, Karim; Kroemer, Guido; Zitvogel, Laurence. - In: JOURNAL FOR IMMUNOTHERAPY OF CANCER. - ISSN 2051-1426. - 10:3(2022), pp. e00419101-e00419112. [10.1136/jitc-2021-004191]
File in questo prodotto:
File Dimensione Formato  
e004191.full (1).pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 9.31 MB
Formato Adobe PDF
9.31 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355076
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 20
social impact