Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer / Terrisse, S., Goubet, A., Ueda, K., Thomas, A.M., Quiniou, V., Thelemaque, C., Dunsmore, G., Clave, E., Gamat-Huber, M., Yonekura, S., Ferrere, G., Rauber, C., Pham, H.P., Fahrner, J., Pizzato, E., Ly, P., Fidelle, M., Mazzenga, M., Costa Silva, C.A., Armanini, F., et al.. - In: JOURNAL FOR IMMUNOTHERAPY OF CANCER. - ISSN 2051-1426. - 10:3(2022), pp. e00419101-e00419112. [10.1136/jitc-2021-004191]
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer
Thomas, Andrew Maltez;Armanini, Federica;Pinto, Federica;Asnicar, Francesco;Segata, Nicola;
2022-01-01
Abstract
Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.| File | Dimensione | Formato | |
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