Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer / Terrisse, Safae; Goubet, Anne-Gaelle; Ueda, Kousuke; Thomas, Andrew Maltez; Quiniou, Valentin; Thelemaque, Cassandra; Dunsmore, Garett; Clave, Emmanuel; Gamat-Huber, Melissa; Yonekura, Satoru; Ferrere, Gladys; Rauber, Conrad; Pham, Hang Phuong; Fahrner, Jean-Eudes; Pizzato, Eugenie; Ly, Pierre; Fidelle, Marine; Mazzenga, Marine; Costa Silva, Carolina Alves; Armanini, Federica; Pinto, Federica; Asnicar, Francesco; Daillère, Romain; Derosa, Lisa; Richard, Corentin; Blanchard, Pierre; Routy, Bertrand; Culine, Stéphane; Opolon, Paule; Silvin, Aymeric; Ginhoux, Florent; Toubert, Antoine; Segata, Nicola; Mcneel, Douglas G; Fizazi, Karim; Kroemer, Guido; Zitvogel, Laurence. - In: JOURNAL FOR IMMUNOTHERAPY OF CANCER. - ISSN 2051-1426. - 10:3(2022), pp. e00419101-e00419112. [10.1136/jitc-2021-004191]
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer
Thomas, Andrew Maltez;Armanini, Federica;Pinto, Federica;Asnicar, Francesco;Segata, Nicola;
2022-01-01
Abstract
Prostate cancer (PC) responds to androgen deprivation therapy (ADT) usually in a transient fashion, progressing from hormone-sensitive PC (HSPC) to castration-resistant PC (CRPC). We investigated a mouse model of PC as well as specimens from PC patients to unravel an unsuspected contribution of thymus-derived T lymphocytes and the intestinal microbiota in the efficacy of ADT.| File | Dimensione | Formato | |
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