Massignan, Tania
Massignan, Tania
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein
2016-01-01 Massignan, Tania; Cimini, Sara; Stincardini, Claudia; Cerovic, Milica; Vanni, Ilaria; Elezgarai, Saioa R.; Moreno, Jorge; Stravalaci, Matteo; Negro, Alessandro; Sangiovanni, Valeria; Restelli, Elena; Riccardi, Geraldina; Gobbi, Marco; Castilla, Joaquín; Borsello, Tiziana; Nonno, Romolo; Biasini, Emiliano
A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide
2011-01-01 Massignan, Tania; Biasini, Emiliano; Harris, David A.
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
2013-01-01 Biasini, Emiliano; Unterberger, Ursula; Solomon, Isaac H.; Massignan, Tania; Senatore, Assunta; Bian, Hejiao; Voigtlaender, Till; Bowman, Frederick P.; Bonetto, Valentina; Chiesa, Roberto; Luebke, Jennifer; Toselli, Paul; Harris, David A.
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein
2010-01-01 Massignan, Tania; Stewart, Richard S.; Biasini, Emiliano; Solomon, Isaac H.; Bonetto, Valentina; Chiesa, Roberto; Harris, David A.
A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity
2017-01-01 Massignan, Tania; Sangiovanni, Valeria; Biggi, Silvia; Stincardini, Claudia; Elezgarai, Saioa R.; Maietta, Giulia; Andreev, Ivan A.; Ratmanova, Nina K.; Belov, Dmitry S.; Lukyanenko, Evgeny R.; Belov, Grigory M.; Barreca, Maria Letizia; Altieri, Andrea; Kurkin, Alexander V.; Biasini, Emiliano
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein
2017-01-01 Stincardini, Claudia; Massignan, Tania; Biggi, Silvia; Elezgarai, Saioa R.; Sangiovanni, Valeria; Vanni, Ilaria; Pancher, Michael; Adami, Valentina; Moreno, Jorge; Stravalaci, Matteo; Maietta, Giulia; Gobbi, Marco; Negro, Alessandro; Requena, Jesús R.; Castilla, Joaquãn; Nonno, Romolo; Biasini, Emiliano
An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity
2011-01-01 Solomon, Isaac H.; Khatri, Natasha; Biasini, Emiliano; Massignan, Tania; Huettner, James E.; Harris, David A.
Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity
2006-01-01 Biasini, Emiliano; Massignan, Tania; Fioriti, Luana; Rossi, Valentina; Dossena, Sara; Salmona, Mario; Forloni, Gianluigi; Bonetto, Valentina; Chiesa, Roberto
Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis
2009-01-01 Basso, Manuela; Samengo, Giuseppina; Nardo, Giovanni; Massignan, Tania; D'Alessandro, Giuseppina; Tartari, Silvia; Cantoni, Lavinia; Marino, Marianna; Cheroni, Cristina; De Biasi, Silvia; Giordana, Maria Teresa; Strong, Michael J; Estevez, Alvaro G; Salmona, Mario; Bendotti, Caterina; Bonetto, Valentina
Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface
2020-01-01 Biggi, S.; Pancher, M.; Stincardini, C.; Luotti, S.; Massignan, T.; Dalle Vedove, A.; Astolfi, A.; Gatto, P.; Lolli, G.; Barreca, M. L.; Bonetto, V.; Adami, V.; Biasini, E.
Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice
2006-01-01 Basso, Manuela; Massignan, Tania; Samengo, Giuseppina; Cheroni, Cristina; De Biasi, Silvia; Salmona, Mario; Bendotti, Caterina; Bonetto, Valentina
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
2021-01-01 Linsenmeier, Luise; Mohammadi, Behnam; Shafiq, Mohsin; Frontzek, Karl; Bär, Julia; Shrivastava, Amulya N; Damme, Markus; Song, Feizhi; Schwarz, Alexander; Da Vela, Stefano; Massignan, Tania; Jung, Sebastian; Correia, Angela; Schmitz, Matthias; Puig, Berta; Hornemann, Simone; Zerr, Inga; Tatzelt, Jörg; Biasini, Emiliano; Saftig, Paul; Schweizer, Michaela; Svergun, Dmitri; Amin, Ladan; Mazzola, Federica; Varani, Luca; Thapa, Simrika; Gilch, Sabine; Schätzl, Hermann; Harris, David A; Triller, Antoine; Mikhaylova, Marina; Aguzzi, Adriano; Altmeppen, Hermann C; Glatzel, Markus
Mutant prion protein expression is associated with an alteration of the rab GDP dissociation inhibitor α (GDI)/rab11 pathway
2010-01-01 Massignan, Tania; Biasini, Emiliano; Lauranzano, Eliana; Veglianese, Pietro; Pignataro, Mauro; Fioriti, Luana; Harris, David A.; Salmona, Mario; Chiesa, Roberto; Bonetto, Valentina
Pharmacological inactivation of the prion protein by targeting a folding intermediate
2021-01-01 Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Rigoli, Marta; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Bonaldo, Valerio; Maietta, Giulia; Lorenzo, Nuria L; Fernandez, Leticia C; Codeseira, Yaiza B; Tosatto, Laura; Linsenmeier, Luise; Vignoli, Beatrice; Petris, Gianluca; Gasparotto, Dino; Pennuto, Maria; Guella, Graziano; Canossa, Marco; Altmeppen, Hermann C; Lolli, Graziano; Biressi, Stefano; Pastor, Manuel M; Requena, Jesús R; Mancini, Ines; Barreca, Maria L; Faccioli, Pietro; Biasini, Emiliano
Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis
2005-01-01 Casoni, Filippo; Basso, Manuela; Massignan, Tania; Gianazza, Elisabetta; Cheroni, Cristina; Salmona, Mario; Bendotti, Caterina; Bonetto, Valentina
Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse
2007-01-01 Massignan, Tania; Casoni, Filippo; Basso, Manuela; Stefanazzi, Paola; Biasini, Emiliano; Tortarolo, Massimo; Salmona, Mario; Gianazza, Elisabetta; Bendotti, Caterina; Bonetto, Valentina
Redox regulation of cyclophilin A by glutathionylation
2006-01-01 Ghezzi, Pietro; Casagrande, Simona; Massignan, Tania; Basso, Manuela; Bellacchio, Emanuele; Mollica, Luca; Biasini, Emiliano; Tonelli, Rossella; Eberini, Ivano; Gianazza, Elisabetta; Dai, Wei Wei; Fratelli, Maddalena; Salmona, Mario; Sherry, Barbara; Bonetto, Valentina
The hydrophobic core region governs mutant prion protein aggregation and intracellular retention
2010-01-01 Biasini, Emiliano; Tapella, Laura; Restelli, Elena; Pozzoli, Manuela; Massignan, Tania; Chiesa, Roberto
The N-terminal, polybasic region of PrP C dictates the efficiency of prion propagation by binding to PrP Sc
2012-01-01 Turnbaugh, Jessie A.; Unterberger, Ursula; Saá, Paula; Massignan, Tania; Fluharty, Brian R.; Bowman, Frederick P.; Miller, Michael B.; Supattapone, Surachai; Biasini, Emiliano; Harris, David A.
The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells
2012-01-01 Biasini, Emiliano; Turnbaugh, Jessie A.; Massignan, Tania; Veglianese, Pietro; Forloni, Gianluigi; Bonetto, Valentina; Chiesa, Roberto; Harris, David A.