Purpose: Variations in the oral microbiome are potentially implicated in social inequalities in oral disease, cancers, and metabolic disease. We describe sociodemographic variation of oral microbiomes in a diverse sample. Methods: We performed 16S rRNA sequencing on mouthwash specimens in a subsample (n = 282) of the 2013–2014 population-based New York City Health and Nutrition Examination Study. We examined differential abundance of 216 operational taxonomic units, and alpha and beta diversity by age, sex, income, education, nativity, and race/ethnicity. For comparison, we examined differential abundance by diet, smoking status, and oral health behaviors. Results: Sixty-nine operational taxonomic units were differentially abundant by any sociodemographic variable (false discovery rate < 0.01), including 27 by race/ethnicity, 21 by family income, 19 by education, 3 by sex. We found 49 differentially abundant by smoking status, 23 by diet, 12 by oral health behaviors. Genera differing for multiple sociodemographic characteristics included Lactobacillus, Prevotella, Porphyromonas, Fusobacterium. Conclusions: We identified oral microbiome variation consistent with health inequalities, more taxa differing by race/ethnicity than diet, and more by SES variables than oral health behaviors. Investigation is warranted into possible mediating effects of the oral microbiome in social disparities in oral and metabolic diseases and cancers.

Sociodemographic variation in the oral microbiome / Renson, A.; Jones, H. E.; Beghini, F.; Segata, N.; Zolnik, C. P.; Usyk, M.; Moody, T. U.; Thorpe, L.; Burk, R.; Waldron, L.; Dowd, J. B.. - In: ANNALS OF EPIDEMIOLOGY. - ISSN 1047-2797. - 35:(2019), pp. 73-80.e2. [10.1016/j.annepidem.2019.03.006]

Sociodemographic variation in the oral microbiome

Beghini F.;Segata N.;Waldron L.;
2019

Abstract

Purpose: Variations in the oral microbiome are potentially implicated in social inequalities in oral disease, cancers, and metabolic disease. We describe sociodemographic variation of oral microbiomes in a diverse sample. Methods: We performed 16S rRNA sequencing on mouthwash specimens in a subsample (n = 282) of the 2013–2014 population-based New York City Health and Nutrition Examination Study. We examined differential abundance of 216 operational taxonomic units, and alpha and beta diversity by age, sex, income, education, nativity, and race/ethnicity. For comparison, we examined differential abundance by diet, smoking status, and oral health behaviors. Results: Sixty-nine operational taxonomic units were differentially abundant by any sociodemographic variable (false discovery rate < 0.01), including 27 by race/ethnicity, 21 by family income, 19 by education, 3 by sex. We found 49 differentially abundant by smoking status, 23 by diet, 12 by oral health behaviors. Genera differing for multiple sociodemographic characteristics included Lactobacillus, Prevotella, Porphyromonas, Fusobacterium. Conclusions: We identified oral microbiome variation consistent with health inequalities, more taxa differing by race/ethnicity than diet, and more by SES variables than oral health behaviors. Investigation is warranted into possible mediating effects of the oral microbiome in social disparities in oral and metabolic diseases and cancers.
Renson, A.; Jones, H. E.; Beghini, F.; Segata, N.; Zolnik, C. P.; Usyk, M.; Moody, T. U.; Thorpe, L.; Burk, R.; Waldron, L.; Dowd, J. B.
Sociodemographic variation in the oral microbiome / Renson, A.; Jones, H. E.; Beghini, F.; Segata, N.; Zolnik, C. P.; Usyk, M.; Moody, T. U.; Thorpe, L.; Burk, R.; Waldron, L.; Dowd, J. B.. - In: ANNALS OF EPIDEMIOLOGY. - ISSN 1047-2797. - 35:(2019), pp. 73-80.e2. [10.1016/j.annepidem.2019.03.006]
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1047279718306781-main.pdf

Solo gestori archivio

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.15 MB
Formato Adobe PDF
2.15 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/241514
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
social impact