Novel neural stem cell systems.

Neural stem cells are cells that can self-renew ad infinitum and have the potential to generate immature precursors and mature cells of both neuronal and glial lineages. During recent years, neural stem cells gained attention as major candidates for regenerative and cell replacement therapies in various pathological brain conditions; however, they have recently revealed unforeseen valuable characters. Here the authors review on the state of the field, with a particular focus on the most recent results on the optimisation of neural stem cells isolation/ derivation and homogeneous long-term expansion, highlighting advantages of this resource and outlining their potential applications. Bearing in mind that stem-cell based therapies for the diseased and injured brain are still far from being a reality, these cells have been recently opened up to valuable exploitation for disease modelling, drug discovery and toxicology tests as short-term applications.

Titolo: Novel neural stem cell systems.
Autori: Conti, Luciano; Cattaneo, E; Papadimou, E.
Autori Unitn: 
Conti, Luciano
mostra contributor esterni 
Titolo del periodico: EXPERT OPINION ON BIOLOGICAL THERAPY
Anno di pubblicazione: 2008
Numero e parte del fascicolo: 2
Codice identificativo Scopus: 2-s2.0-38949093019
Codice identificativo Pubmed: 18194072
Codice identificativo WOS: WOS:000252878300003
Digital Object Identifier (DOI): http://dx.doi.org/10.1517/14712598.8.2.153
Handle: http://hdl.handle.net/11572/99134
Appare nelle tipologie:03.1 Articolo su rivista (Journal article)

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