Metal additive manufacturing of lattice-based orthopedic implants: A comprehensive review of requirements and design strategies

This scoping review synthesizes recent advancements in the design and manufacturing of metallic additively manufactured lattice-based orthopedic implants. The review begins with an in-depth discussion on material selection, exploring the range of metals suitable for orthopedic applications, and progresses to detail the evolution of design methodologies, which now incorporate bio-inspired concepts and data-driven models such as inverse design. These innovative approaches significantly enhance the customization and functionality of bone implants, offering unprecedented opportunities for tailored patient care. Additionally, the review analyzes the current standards and regulations that govern the development and implementation of these implants in clinical settings. It outlines the necessary steps and considerations for compliance, emphasizing the importance of these frameworks in ensuring the safe and effective transition of lattice-based orthopedic implants from theoretical models to practical solutions in healthcare. By bridging the gap between cutting-edge research and clinical application, this review aims to serve as a crucial resource for researchers, engineers, and medical professionals. It not only encapsulates the state-ofthe-art in implant technology but also highlights the collaborative efforts required to advance the field and overcome existing challenges. The ultimate goal is to pave the way for next-generation bone implants that are highly effective, safe, and optimized for individual patient needs