Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine association of these genes with patient's outcome.
PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases / De Re, Valli; Tornesello, Maria Lina; De Zorzi, Mariangela; Caggiari, Laura; Pezzuto, Francesca; Leone, Patrizia; Racanelli, Vito; Lauletta, Gianfranco; Zanussi, Stefania; Repetto, Ombretta; Gragnani, Laura; Rossi, Francesca Maria; Dolcetti, Riccardo; Zignego, Anna Linda; Buonaguro, Franco M; Steffan, Agostino. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - 41:1(2021), pp. 133-149. [10.1111/liv.14667]
PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases
Racanelli, Vito;
2021-01-01
Abstract
Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine association of these genes with patient's outcome.| File | Dimensione | Formato | |
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