Ablative and locoregional treatment options, such as radiofrequency, ethanol injection, microwave, and cryoablation, as well as irreversible electroporation, are effective therapies for early-stage hepatocellular carcinoma (HCC). Hepatocyte death caused by ablative procedures is known to increase the release of tumor-associated antigen, thus enhancing tumor immunogenicity. In addition, the heat ablative resection induces pyroptotic cell death accompanied by the release of several inflammatory factors and immune-related proteins, including damage-associated molecular patterns (DAMPs), heat shock proteins (HSPs), ficolin 3, ATP, and DNA/RNA, which potentiate the antitumoral immune response. Surgical approaches that enhance tumor necrosis and reduce hypoxia in the residual liver parenchyma have been shown to increase the disease-free survival rate by reducing the host's immunosuppressive response. Scalpel devices and targeted surgical approach combined with immune-modulating drugs are an interesting and promising area to maximize therapeutic outcomes after HCC ablation.

Hepatocellular Carcinoma Intrinsic Cell Death Regulates Immune Response and Prognosis / De Re, Valli; Rossetto, Anna; Rosignoli, Alessandro; Muraro, Elena; Racanelli, Vito; Tornesello, Maria Lina; Zompicchiatti, Aron; Uzzau, Alessandro. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 12:(2022), pp. 89770301-89770312. [10.3389/fonc.2022.897703]

Hepatocellular Carcinoma Intrinsic Cell Death Regulates Immune Response and Prognosis

Racanelli, Vito;
2022-01-01

Abstract

Ablative and locoregional treatment options, such as radiofrequency, ethanol injection, microwave, and cryoablation, as well as irreversible electroporation, are effective therapies for early-stage hepatocellular carcinoma (HCC). Hepatocyte death caused by ablative procedures is known to increase the release of tumor-associated antigen, thus enhancing tumor immunogenicity. In addition, the heat ablative resection induces pyroptotic cell death accompanied by the release of several inflammatory factors and immune-related proteins, including damage-associated molecular patterns (DAMPs), heat shock proteins (HSPs), ficolin 3, ATP, and DNA/RNA, which potentiate the antitumoral immune response. Surgical approaches that enhance tumor necrosis and reduce hypoxia in the residual liver parenchyma have been shown to increase the disease-free survival rate by reducing the host's immunosuppressive response. Scalpel devices and targeted surgical approach combined with immune-modulating drugs are an interesting and promising area to maximize therapeutic outcomes after HCC ablation.
2022
De Re, Valli; Rossetto, Anna; Rosignoli, Alessandro; Muraro, Elena; Racanelli, Vito; Tornesello, Maria Lina; Zompicchiatti, Aron; Uzzau, Alessandro
Hepatocellular Carcinoma Intrinsic Cell Death Regulates Immune Response and Prognosis / De Re, Valli; Rossetto, Anna; Rosignoli, Alessandro; Muraro, Elena; Racanelli, Vito; Tornesello, Maria Lina; Zompicchiatti, Aron; Uzzau, Alessandro. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 12:(2022), pp. 89770301-89770312. [10.3389/fonc.2022.897703]
File in questo prodotto:
File Dimensione Formato  
2022 HCV De RE fonc-12-897703.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 1.02 MB
Formato Adobe PDF
1.02 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/386977
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact