Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects with TTS were enrolled and followed for a median of 3 years. Circulating levels of CA-15.3, CA-19.9 and CEA were evaluated at admission, after 72 h and at discharge. Incidence of MACE during hospitalization and follow-up were recorded. Forty-three (46%) patients experienced MACE during hospitalization. These patients had increased admission levels of CEA (4.3 ± 6.2 vs. 2.2 ± 1.5 ng/mL, p = 0.03). CEA levels were higher in subjects with in-hospital MACE. At long term follow-up, CEA and CA-19.9 levels were associated with increased risk of death (log rank p < 0.01, HR = 5.3, 95% CI 1.9-14.8, HR = 7.8 95% CI 2.4-25.1, respectively, p < 0.01). At multivariable analysis levels higher than median of CEA, CA-19.9 or both were independent predictors of death at long term (Log-Rank p < 0.01). Having both CEA and CA-19.9 levels above median (> 2 ng/mL, > 8 UI/mL respectively) was associated with an increased risk of mortality of 11.8 (95% CI 2.6-52.5, p = 0.001) at follow up. Increased CEA and CA-19.9 serum levels are associated with higher risk of death at long-term follow up in patients with TTS. CEA serum levels are correlated with in-hospital MACE.

Prognostic role of neoplastic markers in Takotsubo syndrome / Santoro, Francesco; Zimotti, Tecla; Mallardi, Adriana; Leopizzi, Alessandra; Vitale, Enrica; Tarantino, Nicola; Ferraretti, Armando; Solimando, Antonio Giovanni; Racanelli, Vito; Iacoviello, Massimo; Cannone, Michele; Di Biase, Matteo; Brunetti, Natale Daniele. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021), pp. 165481-165488. [10.1038/s41598-021-95990-9]

Prognostic role of neoplastic markers in Takotsubo syndrome

Racanelli, Vito;
2021-01-01

Abstract

Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects with TTS were enrolled and followed for a median of 3 years. Circulating levels of CA-15.3, CA-19.9 and CEA were evaluated at admission, after 72 h and at discharge. Incidence of MACE during hospitalization and follow-up were recorded. Forty-three (46%) patients experienced MACE during hospitalization. These patients had increased admission levels of CEA (4.3 ± 6.2 vs. 2.2 ± 1.5 ng/mL, p = 0.03). CEA levels were higher in subjects with in-hospital MACE. At long term follow-up, CEA and CA-19.9 levels were associated with increased risk of death (log rank p < 0.01, HR = 5.3, 95% CI 1.9-14.8, HR = 7.8 95% CI 2.4-25.1, respectively, p < 0.01). At multivariable analysis levels higher than median of CEA, CA-19.9 or both were independent predictors of death at long term (Log-Rank p < 0.01). Having both CEA and CA-19.9 levels above median (> 2 ng/mL, > 8 UI/mL respectively) was associated with an increased risk of mortality of 11.8 (95% CI 2.6-52.5, p = 0.001) at follow up. Increased CEA and CA-19.9 serum levels are associated with higher risk of death at long-term follow up in patients with TTS. CEA serum levels are correlated with in-hospital MACE.
2021
1
Santoro, Francesco; Zimotti, Tecla; Mallardi, Adriana; Leopizzi, Alessandra; Vitale, Enrica; Tarantino, Nicola; Ferraretti, Armando; Solimando, Antonio Giovanni; Racanelli, Vito; Iacoviello, Massimo; Cannone, Michele; Di Biase, Matteo; Brunetti, Natale Daniele
Prognostic role of neoplastic markers in Takotsubo syndrome / Santoro, Francesco; Zimotti, Tecla; Mallardi, Adriana; Leopizzi, Alessandra; Vitale, Enrica; Tarantino, Nicola; Ferraretti, Armando; Solimando, Antonio Giovanni; Racanelli, Vito; Iacoviello, Massimo; Cannone, Michele; Di Biase, Matteo; Brunetti, Natale Daniele. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021), pp. 165481-165488. [10.1038/s41598-021-95990-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/386974
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