In order to investigate the possible role of Epstein–Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case–control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A included 16 patients with diagnosis of SLE and group B included 15 healthy individuals. Salivary swab samples were collected and subjected to molecular screening by real-time quantitative PCR (qPCR) for the detection of EBV DNA. EBV DNA was significantly detected in 8/16 (50%) SLE patients and in 5/7 (71.4%) subjects with SLE-associated oral lesions. Since EBV is one of the most common viruses in the human population, it is difficult to understand if it is the causative agent of SLE or, vice versa, if SLE is able to trigger the reactivation of EBV. This study highlights a significant association between the presence of EBV and both SLE and SLE-related oral lesions and provides rationale for further investigation into the role of EBV in SLE pathogenesis

Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions / Buonavoglia, Alessio; Patrizia Leone, Patrizia; Prete, Marcella; Solimando, Antonio Giovanni; Guastadisegno, Chiara; Lanave, Gianvito; Camero, Michele; Martella, Vito; Lo Muzio, Lorenzo; Racanelli, Vito. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:21(2021), pp. 49951-49958. [10.3390/jcm10214995]

Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions

Racanelli, Vito
2021-01-01

Abstract

In order to investigate the possible role of Epstein–Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case–control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A included 16 patients with diagnosis of SLE and group B included 15 healthy individuals. Salivary swab samples were collected and subjected to molecular screening by real-time quantitative PCR (qPCR) for the detection of EBV DNA. EBV DNA was significantly detected in 8/16 (50%) SLE patients and in 5/7 (71.4%) subjects with SLE-associated oral lesions. Since EBV is one of the most common viruses in the human population, it is difficult to understand if it is the causative agent of SLE or, vice versa, if SLE is able to trigger the reactivation of EBV. This study highlights a significant association between the presence of EBV and both SLE and SLE-related oral lesions and provides rationale for further investigation into the role of EBV in SLE pathogenesis
2021
21
Buonavoglia, Alessio; Patrizia Leone, Patrizia; Prete, Marcella; Solimando, Antonio Giovanni; Guastadisegno, Chiara; Lanave, Gianvito; Camero, Michele...espandi
Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions / Buonavoglia, Alessio; Patrizia Leone, Patrizia; Prete, Marcella; Solimando, Antonio Giovanni; Guastadisegno, Chiara; Lanave, Gianvito; Camero, Michele; Martella, Vito; Lo Muzio, Lorenzo; Racanelli, Vito. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:21(2021), pp. 49951-49958. [10.3390/jcm10214995]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/386880
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