One of the hallmarks of cancer is angiogenesis, a series of events leading to the formation of the abnormal vascular network required for tumor growth, development, progression, and metastasis. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs whose functions include modulation of the expression of pro- and anti-angiogenic factors and regulation of the function of vascular endothelial cells. Vascular-associated microRNAs can be either pro- or anti-angiogenic. In cancer, miRNA expression levels are deregulated and typically vary during tumor progression. Experimental data indicate that the tumor phenotype can be modified by targeting miRNA expression. Based on these observations, miRNAs may be promising targets for the development of novel anti-angiogenic therapies. This review discusses the role of various miRNAs and their targets in tumor angiogenesis, describes the strategies and challenges of miRNA-based anti-angiogenic therapies and explores the potential use of miRNAs as biomarkers for anti-angiogenic therapy response.

Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs / Leone, Patrizia; Buonavoglia, Alessio; Fasano, Rossella; Solimando, Antonio Giovanni; De Re, Valli; Cicco, Sebastiano; Vacca, Angelo; Racanelli, Vito. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:12(2019), pp. 203001-203020. [10.3390/jcm8122030]

Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs

Racanelli, Vito
2019-01-01

Abstract

One of the hallmarks of cancer is angiogenesis, a series of events leading to the formation of the abnormal vascular network required for tumor growth, development, progression, and metastasis. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs whose functions include modulation of the expression of pro- and anti-angiogenic factors and regulation of the function of vascular endothelial cells. Vascular-associated microRNAs can be either pro- or anti-angiogenic. In cancer, miRNA expression levels are deregulated and typically vary during tumor progression. Experimental data indicate that the tumor phenotype can be modified by targeting miRNA expression. Based on these observations, miRNAs may be promising targets for the development of novel anti-angiogenic therapies. This review discusses the role of various miRNAs and their targets in tumor angiogenesis, describes the strategies and challenges of miRNA-based anti-angiogenic therapies and explores the potential use of miRNAs as biomarkers for anti-angiogenic therapy response.
2019
12
Leone, Patrizia; Buonavoglia, Alessio; Fasano, Rossella; Solimando, Antonio Giovanni; De Re, Valli; Cicco, Sebastiano; Vacca, Angelo; Racanelli, Vito
Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs / Leone, Patrizia; Buonavoglia, Alessio; Fasano, Rossella; Solimando, Antonio Giovanni; De Re, Valli; Cicco, Sebastiano; Vacca, Angelo; Racanelli, Vito. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:12(2019), pp. 203001-203020. [10.3390/jcm8122030]
File in questo prodotto:
File Dimensione Formato  
2019 JCM Rev MiRNA.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 741.47 kB
Formato Adobe PDF
741.47 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/386862
Citazioni
  • ???jsp.display-item.citation.pmc??? 47
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 60
social impact