A Semi-Unsupervised Segmentation Methodology Based on Texture Recognition for Radiomics: A Preliminary Study on Brain Tumours

Because of the intrinsic anatomic complexity of the brain structures, brain tumors have a high mortality and disability rate, and an early diagnosis is mandatory to contain damages. The commonly used biopsy is the diagnostic gold standard method, but it is invasive and, due to intratumoral heterogeneity, biopsies may lead to an incorrect result. Moreover, some tumors cannot be resectable if located in critical eloquent areas. On the other hand, medical imaging procedures can evaluate the entire tumor in a non-invasive and reproducible way. Radiomics is an emerging diagnosis technique based on quantitative medical image analyses, which makes use of data provided by non-invasive diagnosis techniques such as X-ray, computer-tomography (CT), magnetic resonance (MR), and proton emission tomography (PET). Radiomics techniques require the comprehensive analysis of huge numbers of medical images to extract a large and useful number of phenotypic features (usually called radiomics biomarkers). The goal is to explore and obtain the associations between features of tumors, diagnosis and patients' prognoses to choose the best treatments and maximize the patient's survival rate. Current radiomics techniques are not standardized in term of segmentation, feature extraction, and selection, moreover, the decision on suitable therapies still requires the supervision of an expert doctor. In this paper, we propose a semi-automatic methodology aimed to help the identification and segmentation of malignant tissues by using the combination of binary texture recognition, growing area algorithm, and machine learning techniques. In particular, the proposed method not only helps to better identify pathologic tissues but also permits to analyze in a fast way the huge amount of data, in Dicom format, provided by non-invasive diagnostic techniques. A preliminary experimental assessment has been conducted, considering a real MRI database of brain tumors. The method has been compared with the segmentation software's tools "slicer 3D". The obtained results are quite promising and demonstrate the potentialities of the proposed semi-unsupervised segmentation methodology.