Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual's sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning.Methods Healthy adults' data (N = 953 [41% twins]) were analysed from the PREDICT dietary intervention trial. Participants consumed isoenergetic standardised meals over 2 weeks in the clinic and at home. Actigraphy was used to assess sleep variables (duration, efficiency, timing) and continuous glucose monitors were used to measure glycaemic variation (>8000 meals).Results Sleep variables were significantly associated with postprandial glycaemic control (2 h incremental AUC), at both between- and within-person levels. Sleep period time interacted with meal type, with a smaller effect of poor sleep on postprandial blood glucose levels when high-carbohydrate (low fat/protein) (p(interaction) = 0.02) and high-fat (p(interaction) = 0.03) breakfasts were consumed compared with a reference 75 g OGTT. Within-person sleep period time had a similar interaction (high carbohydrate: p(interaction) = 0.001, high fat: p(interaction) = 0.02). Within- and between-person sleep efficiency were significantly associated with lower postprandial blood glucose levels irrespective of meal type (both p < 0.03). Later sleep midpoint (time deviation from midnight) was found to be significantly associated with higher postprandial glucose, in both between-person and within-person comparisons (p = 0.035 and p = 0.051, respectively).Conclusions/interpretation Poor sleep efficiency and later bedtime routines are associated with more pronounced postprandial glycaemic responses to breakfast the following morning. A person's deviation from their usual sleep pattern was also associated with poorer postprandial glycaemic control. These findings underscore sleep as a modifiable, non-pharmacological therapeutic target for the optimal regulation of human metabolic health.

Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions / Tsereteli, Neli; Vallat, Raphael; Fernandez-Tajes, Juan; Delahanty, Linda M; Ordovas, Jose M; Drew, David A; Valdes, Ana M; Segata, Nicola; Chan, Andrew T; Wolf, Jonathan; Berry, Sarah E; Walker, Matthew P; Spector, Timothy D; Franks, Paul W. - In: DIABETOLOGIA. - ISSN 1432-0428. - 65:2(2022), pp. 356-365. [10.1007/s00125-021-05608-y]

Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions

Segata, Nicola;
2022-01-01

Abstract

Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual's sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning.Methods Healthy adults' data (N = 953 [41% twins]) were analysed from the PREDICT dietary intervention trial. Participants consumed isoenergetic standardised meals over 2 weeks in the clinic and at home. Actigraphy was used to assess sleep variables (duration, efficiency, timing) and continuous glucose monitors were used to measure glycaemic variation (>8000 meals).Results Sleep variables were significantly associated with postprandial glycaemic control (2 h incremental AUC), at both between- and within-person levels. Sleep period time interacted with meal type, with a smaller effect of poor sleep on postprandial blood glucose levels when high-carbohydrate (low fat/protein) (p(interaction) = 0.02) and high-fat (p(interaction) = 0.03) breakfasts were consumed compared with a reference 75 g OGTT. Within-person sleep period time had a similar interaction (high carbohydrate: p(interaction) = 0.001, high fat: p(interaction) = 0.02). Within- and between-person sleep efficiency were significantly associated with lower postprandial blood glucose levels irrespective of meal type (both p < 0.03). Later sleep midpoint (time deviation from midnight) was found to be significantly associated with higher postprandial glucose, in both between-person and within-person comparisons (p = 0.035 and p = 0.051, respectively).Conclusions/interpretation Poor sleep efficiency and later bedtime routines are associated with more pronounced postprandial glycaemic responses to breakfast the following morning. A person's deviation from their usual sleep pattern was also associated with poorer postprandial glycaemic control. These findings underscore sleep as a modifiable, non-pharmacological therapeutic target for the optimal regulation of human metabolic health.
2022
2
Tsereteli, Neli; Vallat, Raphael; Fernandez-Tajes, Juan; Delahanty, Linda M; Ordovas, Jose M; Drew, David A; Valdes, Ana M; Segata, Nicola; Chan, Andrew T; Wolf, Jonathan; Berry, Sarah E; Walker, Matthew P; Spector, Timothy D; Franks, Paul W
Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions / Tsereteli, Neli; Vallat, Raphael; Fernandez-Tajes, Juan; Delahanty, Linda M; Ordovas, Jose M; Drew, David A; Valdes, Ana M; Segata, Nicola; Chan, Andrew T; Wolf, Jonathan; Berry, Sarah E; Walker, Matthew P; Spector, Timothy D; Franks, Paul W. - In: DIABETOLOGIA. - ISSN 1432-0428. - 65:2(2022), pp. 356-365. [10.1007/s00125-021-05608-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/355075
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