Immune system dysfunction has been described in autism spectrum disorder. Here we tested the hypothesis that cerebellar defects are accompanied by immune dysfunction in adult mice lacking the autism-candidate gene Engrailed 2 (En2). Gene ontology analyses revealed that biological processes related to immune function were over-represented in the cerebellar transcriptome of En2− /− mice. Pro-inflammatory molecules and chemokines were reduced in the En2− /− cerebellum compared to controls. Conversely, pro-inflammatory molecules were increased in the peripheral blood of mutant mice. Our results suggest a link between immune dysfunction and cerebellar defects detected in En2− /− mice.

Immune dysfunction in the cerebellum of mice lacking the autism candidate gene Engrailed 2 / Pangrazzi, Luca; Genovesi, Sacha; Balasco, Luigi; Cerilli, Enrica; Robol, Camilla; Zunino, Giulia; Piazza, Silvano; Provenzano, Giovanni; Bozzi, Yuri. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 367:(2022), pp. 5778701-5778709. [10.1016/j.jneuroim.2022.577870]

Immune dysfunction in the cerebellum of mice lacking the autism candidate gene Engrailed 2

Pangrazzi, Luca;Genovesi, Sacha;Balasco, Luigi;Zunino, Giulia;Piazza, Silvano;Provenzano, Giovanni;Bozzi, Yuri
2022-01-01

Abstract

Immune system dysfunction has been described in autism spectrum disorder. Here we tested the hypothesis that cerebellar defects are accompanied by immune dysfunction in adult mice lacking the autism-candidate gene Engrailed 2 (En2). Gene ontology analyses revealed that biological processes related to immune function were over-represented in the cerebellar transcriptome of En2− /− mice. Pro-inflammatory molecules and chemokines were reduced in the En2− /− cerebellum compared to controls. Conversely, pro-inflammatory molecules were increased in the peripheral blood of mutant mice. Our results suggest a link between immune dysfunction and cerebellar defects detected in En2− /− mice.
Pangrazzi, Luca; Genovesi, Sacha; Balasco, Luigi; Cerilli, Enrica; Robol, Camilla; Zunino, Giulia; Piazza, Silvano; Provenzano, Giovanni; Bozzi, Yuri
Immune dysfunction in the cerebellum of mice lacking the autism candidate gene Engrailed 2 / Pangrazzi, Luca; Genovesi, Sacha; Balasco, Luigi; Cerilli, Enrica; Robol, Camilla; Zunino, Giulia; Piazza, Silvano; Provenzano, Giovanni; Bozzi, Yuri. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 367:(2022), pp. 5778701-5778709. [10.1016/j.jneuroim.2022.577870]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/339554
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