The Intravenous Glucose Tolerance Test is an experimental procedure used to study the glucose-insulin en- docrine regulatory system. An open problem is to construct a model representing simultaneously the entire regulative mechanism. In the past three decades, several models have appeared, but they have not escaped criticisms and drawbacks. In this paper, the authors apply the Metabolic P systems theory for developing new physiologically based models of the glucose-insulin system, which can be applied to the IVGTT. Ten data- sets obtained from literature were considered and an MP model was found for each, which fits the data and explains the regulations of the dynamics. Finally, each model is analysed to define a common pattern which explains, in general, the action of the glucose-insulin control system.

MP Modelling of Glucose-Insulin Interactions in the Intravenous Glucose Tolerance Test / Manca, Vincenzo; Marchetti, Luca; Pagliarini, Roberto. - In: INTERNATIONAL JOURNAL OF NATURAL COMPUTING RESEARCH. - ISSN 1947-928X. - STAMPA. - 2:3(2011), pp. 13-24. [10.4018/jncr.2011070102]

MP Modelling of Glucose-Insulin Interactions in the Intravenous Glucose Tolerance Test

MARCHETTI, Luca;
2011-01-01

Abstract

The Intravenous Glucose Tolerance Test is an experimental procedure used to study the glucose-insulin en- docrine regulatory system. An open problem is to construct a model representing simultaneously the entire regulative mechanism. In the past three decades, several models have appeared, but they have not escaped criticisms and drawbacks. In this paper, the authors apply the Metabolic P systems theory for developing new physiologically based models of the glucose-insulin system, which can be applied to the IVGTT. Ten data- sets obtained from literature were considered and an MP model was found for each, which fits the data and explains the regulations of the dynamics. Finally, each model is analysed to define a common pattern which explains, in general, the action of the glucose-insulin control system.
2011
3
Manca, Vincenzo; Marchetti, Luca; Pagliarini, Roberto
MP Modelling of Glucose-Insulin Interactions in the Intravenous Glucose Tolerance Test / Manca, Vincenzo; Marchetti, Luca; Pagliarini, Roberto. - In: INTERNATIONAL JOURNAL OF NATURAL COMPUTING RESEARCH. - ISSN 1947-928X. - STAMPA. - 2:3(2011), pp. 13-24. [10.4018/jncr.2011070102]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/326078
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