The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.
Notch1 switches progenitor competence in inducing medulloblastoma / Ballabio, C.; Gianesello, M.; Lago, C.; Okonechnikov, K.; Anderle, M.; Aiello, G.; Antonica, F.; Zhang, T.; Gianno, F.; Giangaspero, F.; Hassan, B. A.; Pfister, S. M.; Tiberi, L.. - In: SCIENCE ADVANCES. - ISSN 2375-2548. - 7:26(2021), pp. eabd278101-eabd278113. [10.1126/sciadv.abd2781]
Titolo: | Notch1 switches progenitor competence in inducing medulloblastoma | |
Autori: | Ballabio, C.; Gianesello, M.; Lago, C.; Okonechnikov, K.; Anderle, M.; Aiello, G.; Antonica, F.; Zhang, T.; Gianno, F.; Giangaspero, F.; Hassan, B. A.; Pfister, S. M.; Tiberi, L. | |
Autori Unitn: | ||
Titolo del periodico: | SCIENCE ADVANCES | |
Anno di pubblicazione: | 2021 | |
Numero e parte del fascicolo: | 26 | |
Codice identificativo Scopus: | 2-s2.0-85108698286 | |
Codice identificativo Pubmed: | 34162555 | |
Codice identificativo WOS: | WOS:000664978800013 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1126/sciadv.abd2781 | |
Handle: | http://hdl.handle.net/11572/313784 | |
Citazione: | Notch1 switches progenitor competence in inducing medulloblastoma / Ballabio, C.; Gianesello, M.; Lago, C.; Okonechnikov, K.; Anderle, M.; Aiello, G.; Antonica, F.; Zhang, T.; Gianno, F.; Giangaspero, F.; Hassan, B. A.; Pfister, S. M.; Tiberi, L.. - In: SCIENCE ADVANCES. - ISSN 2375-2548. - 7:26(2021), pp. eabd278101-eabd278113. [10.1126/sciadv.abd2781] | |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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