Autism spectrum disorders (ASD) are a group of neurodevelopmental syndromes with both genetic and environmental origins. Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the severity of ASD. Thus, the administration of anti-inflammatory and antioxidant molecules may represent a promising strategy to counteract pathological behaviors in ASD patients. In the current review, results from recent literature showing how natural antioxidants may be beneficial in the context of ASD will be discussed. Interestingly, many antioxidant molecules available in nature show anti-inflammatory activity. Thus, after introducing ASD and the role of the vitamin E/vitamin C/glutathione network in scavenging intracellular reactive oxygen species (ROS) and the impairments observed with ASD, we discuss the concept of functional food and nutraceutical compounds. Furthermore, the effects of well-known nutraceutical compounds on ASD individuals and animal models of ASD are summarized. Finally, the importance of nutraceutical compounds as support therapy useful in reducing the symptoms in autistic people is discussed.

Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders? / Pangrazzi, Luca; Balasco, Luigi; Bozzi, Yuri. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 2020, 9:12(2020), pp. 118601-118617. [10.3390/antiox9121186]

Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

Pangrazzi, Luca;Balasco, Luigi;Bozzi, Yuri
2020-01-01

Abstract

Autism spectrum disorders (ASD) are a group of neurodevelopmental syndromes with both genetic and environmental origins. Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the severity of ASD. Thus, the administration of anti-inflammatory and antioxidant molecules may represent a promising strategy to counteract pathological behaviors in ASD patients. In the current review, results from recent literature showing how natural antioxidants may be beneficial in the context of ASD will be discussed. Interestingly, many antioxidant molecules available in nature show anti-inflammatory activity. Thus, after introducing ASD and the role of the vitamin E/vitamin C/glutathione network in scavenging intracellular reactive oxygen species (ROS) and the impairments observed with ASD, we discuss the concept of functional food and nutraceutical compounds. Furthermore, the effects of well-known nutraceutical compounds on ASD individuals and animal models of ASD are summarized. Finally, the importance of nutraceutical compounds as support therapy useful in reducing the symptoms in autistic people is discussed.
2020
12
Pangrazzi, Luca; Balasco, Luigi; Bozzi, Yuri
Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders? / Pangrazzi, Luca; Balasco, Luigi; Bozzi, Yuri. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 2020, 9:12(2020), pp. 118601-118617. [10.3390/antiox9121186]
File in questo prodotto:
File Dimensione Formato  
antioxidants-09-01186-v2.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 545.22 kB
Formato Adobe PDF
545.22 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/283888
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 25
social impact