The production of D-ribose by fermentation has received much attention lately, possibly because of the use of this pentose to synthesize antiviral and anti-cancer drugs. This review briefly outlines the methods that have been used to synthesize D-ribose since it was identified in yeast RNA, and focuses in particular on the latest developments in D-ribose fermentation, which have led to D-ribose yields that exceed 90 g/1. Furthermore, the various transketolase-deficient D-ribose-producing mutants that are used, and the biochemical and genetic rationales applied to select them or to enhance their D-ribose productivities, are dealt with. Attention is also drawn to the unusual pleiotropic characteristics of the mutant strains, as well as to the industrial and academic applications of D-ribose.
Production of D-ribose by fermentation / De Wulf, P.; Vandamme, E. J.. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - ELETTRONICO. - 1997, vol. 48:2(1997), pp. 141-148. [10.1007/s002530051029]
Production of D-ribose by fermentation
De Wulf P.;
1997-01-01
Abstract
The production of D-ribose by fermentation has received much attention lately, possibly because of the use of this pentose to synthesize antiviral and anti-cancer drugs. This review briefly outlines the methods that have been used to synthesize D-ribose since it was identified in yeast RNA, and focuses in particular on the latest developments in D-ribose fermentation, which have led to D-ribose yields that exceed 90 g/1. Furthermore, the various transketolase-deficient D-ribose-producing mutants that are used, and the biochemical and genetic rationales applied to select them or to enhance their D-ribose productivities, are dealt with. Attention is also drawn to the unusual pleiotropic characteristics of the mutant strains, as well as to the industrial and academic applications of D-ribose.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
