The purpose of this study was to develop an easy and minimally invasive assay to detect a plasma miRNA profile in frontotemporal dementia (FTD) patients, with the final aim of discriminating between FTD patients and healthy controls (HCs). After a global miRNA profiling, significant downregulation of miR-663a, miR-502-3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. Moreover, miR-663a and miR-502-3p showed significant differences in both genders, whereas miR-206, only in male subjects. To obtain a discriminating measure between FTD patients and HCs, we calculated a combined score of the 3 miRNAs by applying a Bayesian approach and obtaining a classifier with an accuracy of 84.4%. Moreover, for men, combined miRNA levels showed an excellent sensitivity (100%) and a good specificity (87.5%) in distinguishing FTD patients from HCs. All these findings open new hypotheses in the pathophysiology and new perspectives in the diagnosis of a complex pathology as FTD.

Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects / Grasso, Margherita; Piscopo, Paola; Talarico, Giuseppina; Ricci, Leonardo; Crestini, Alessio; Tosto, Giuseppe; Gasparini, Marina; Bruno, Giuseppe; Denti, Michela A.; Confaloni, Annamaria. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - ELETTRONICO. - 2019:84(2019), p. 240. [10.1016/j.neurobiolaging.2019.01.024]

Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects

Grasso, Margherita;Ricci, Leonardo;Denti, Michela A.;
2019-01-01

Abstract

The purpose of this study was to develop an easy and minimally invasive assay to detect a plasma miRNA profile in frontotemporal dementia (FTD) patients, with the final aim of discriminating between FTD patients and healthy controls (HCs). After a global miRNA profiling, significant downregulation of miR-663a, miR-502-3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. Moreover, miR-663a and miR-502-3p showed significant differences in both genders, whereas miR-206, only in male subjects. To obtain a discriminating measure between FTD patients and HCs, we calculated a combined score of the 3 miRNAs by applying a Bayesian approach and obtaining a classifier with an accuracy of 84.4%. Moreover, for men, combined miRNA levels showed an excellent sensitivity (100%) and a good specificity (87.5%) in distinguishing FTD patients from HCs. All these findings open new hypotheses in the pathophysiology and new perspectives in the diagnosis of a complex pathology as FTD.
2019
84
Grasso, Margherita; Piscopo, Paola; Talarico, Giuseppina; Ricci, Leonardo; Crestini, Alessio; Tosto, Giuseppe; Gasparini, Marina; Bruno, Giuseppe; Denti, Michela A.; Confaloni, Annamaria
Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects / Grasso, Margherita; Piscopo, Paola; Talarico, Giuseppina; Ricci, Leonardo; Crestini, Alessio; Tosto, Giuseppe; Gasparini, Marina; Bruno, Giuseppe; Denti, Michela A.; Confaloni, Annamaria. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - ELETTRONICO. - 2019:84(2019), p. 240. [10.1016/j.neurobiolaging.2019.01.024]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/230190
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