Phylogenetic studies of bacteria have been based so far either on a single gene (usually the 16S rRNA) or on concatenated housekeeping genes. For what concerns the genus Mycobacterium these approaches support the separation of rapidly and slowly growing species and the clustering of most species in well-defined phylogenetic groups. The advent of high-throughput shotgun sequencing leads us to revise conventional taxonomy of mycobacteria on the light of genomic data. For this purpose we investigated 89 newly sequenced species in addition to 60 retrieved from GenBank and used the Average Nucleotide Identity pairwise scores to reconstruct phylogenetic relationships within this genus.
The new phylogeny of the genus Mycobacterium: The old and the news / Tortoli, Enrico; Fedrizzi, Tarcisio; Meehan, Conor J; Trovato, Alberto; Grottola, Antonella; Giacobazzi, Elisabetta; Serpini, Giulia Fregni; Tagliazucchi, Sara; Fabio, Anna; Bettua, Clotilde; Bertorelli, Roberto; Frascaro, Francesca; De Sanctis, Veronica; Pecorari, Monica; Jousson, Olivier; Segata, Nicola; Cirillo, Daniela M.. - In: INFECTION GENETICS AND EVOLUTION. - ISSN 1567-1348. - 56:(2017), pp. 19-25. [10.1016/j.meegid.2017.10.013]
The new phylogeny of the genus Mycobacterium: The old and the news
Fedrizzi, Tarcisio;Giacobazzi, Elisabetta;Bettua, Clotilde;Bertorelli, Roberto;De Sanctis, Veronica;Jousson, Olivier;Segata, Nicola;
2017-01-01
Abstract
Phylogenetic studies of bacteria have been based so far either on a single gene (usually the 16S rRNA) or on concatenated housekeeping genes. For what concerns the genus Mycobacterium these approaches support the separation of rapidly and slowly growing species and the clustering of most species in well-defined phylogenetic groups. The advent of high-throughput shotgun sequencing leads us to revise conventional taxonomy of mycobacteria on the light of genomic data. For this purpose we investigated 89 newly sequenced species in addition to 60 retrieved from GenBank and used the Average Nucleotide Identity pairwise scores to reconstruct phylogenetic relationships within this genus.| File | Dimensione | Formato | |
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