Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Vilhjálmsson, Bjarni J.;Yang, Jian;Finucane, Hilary K.;Gusev, Alexander;Lindström, Sara;Ripke, Stephan;Genovese, Giulio;Loh, Po Ru;Bhatia, Gaurav;Do, Ron;Hayeck, Tristan;Won, Hong Hee;Ripke, Stephan;Neale, Benjamin M.;Corvin, Aiden;Walters, James T. R.;Farh, Kai How;Holmans, Peter A.;Lee, Phil;Bulik Sullivan, Brendan;Collier, David A.;Huang, Hailiang;Pers, Tune H.;Agartz, Ingrid;Agerbo, Esben;Albus, Margot;Alexander, Madeline;Amin, Farooq;Bacanu, Silviu A.;Begemann, Martin;Belliveau, Richard A.;Bene, Judit;Bergen, Sarah E.;Bevilacqua, Elizabeth;Bigdeli, Tim B.;Black, Donald W.;Bruggeman, Richard;Buccola, Nancy G.;Buckner, Randy L.;Byerley, William;Cahn, Wiepke;Cai, Guiqing;Campion, Dominique;Cantor, Rita M.;Carr, Vaughan J.;Carrera, Noa;Catts, Stanley V.;Chambert, Kimberly D.;Chan, Raymond C. K.;Chen, Ronald Y. L.;Chen, Eric Y. H.;Cheng, Wei;Cheung, Eric F. C.;Chong, Siow Ann;Cloninger, C. Robert;Cohen, David;Cohen, Nadine;Cormican, Paul;Craddock, Nick;Crowley, James J.;Curtis, David;Davidson, Michael;Davis, Kenneth L.;Degenhardt, Franziska;Del Favero, Jurgen;Delisi, Lynn E.;Demontis, Ditte;Dikeos, Dimitris;Dinan, Timothy;Djurovic, Srdjan;Donohoe, Gary;Drapeau, Elodie;Duan, Jubao;Dudbridge, Frank;Durmishi, Naser;Eichhammer, Peter;Eriksson, Johan;Escott Price, Valentina;Essioux, Laurent;Fanous, Ayman H.;Farrell, Martilias S.;Frank, Josef;Franke, Lude;Freedman, Robert;Freimer, Nelson B.;Friedl, Marion;Friedman, Joseph I.;Fromer, Menachem;Genovese, Giulio;Georgieva, Lyudmila;Gershon, Elliot S.;Giegling, Ina;Giusti Rodrguez, Paola;Godard, Stephanie;Goldstein, Jacqueline I.;Golimbet, Vera;Gopal, Srihari;Gratten, Jacob;Grove, Jakob;De Haan, Lieuwe;Hammer, Christian;Hamshere, Marian L.;Hansen, Mark;Hansen, Thomas;Haroutunian, Vahram;Hartmann, Annette M.;Henskens, Frans A.;Herms, Stefan;Hirschhorn, Joel N.;Hoffmann, Per;Hofman, Andrea;Hollegaard, Mads V.;Hougaard, David M.;Ikeda, Masashi;Joa, Inge;Julia, Antonio;Kahn, Rene S.;Kalaydjieva, Luba;Karachanak Yankova, Sena;Karjalainen, Juha;Kavanagh, David;Keller, Matthew C.;Kelly, Brian J.;Kennedy, James L.;Khrunin, Andrey;Kim, Yunjung;Klovins, Janis;Knowles, James A.;Konte, Bettina;Kucinskas, Vaidutis;Kucinskiene, Zita Ausrele;Kuzelova Ptackova, Hana;Kahler, Anna K.;Laurent, Claudine;Keong, Jimmy Lee Chee;Lee, S. Hong;Legge, Sophie E.;Lerer, Bernard;Li, Miaoxin;Li, Tao;Liang, Kung Yee;Lieberman, Jeffrey;Limborska, Svetlana;Loughland, Carmel M.;Lubinski, Jan;Lnnqvist, Jouko;Macek, Milan;Magnusson, Patrik K. E.;Maher, Brion S.;Maier, Wolfgang;Mallet, Jacques;Marsal, Sara;Mattheisen, Manuel;Mattingsdal, Morten;Mccarley, Robert W.;Mcdonald, Colm;Mcintosh, Andrew M.;Meier, Sandra;Meijer, Carin J.;Melegh, Bela;Melle, Ingrid;Mesholam Gately, Raquelle I.;Metspalu, Andres;Michie, Patricia T.;Milani, Lili;Milanova, Vihra;Mokrab, Younes;Morris, Derek W.;Mors, Ole;Mortensen, Preben B.;Murphy, Kieran C.;Murray, Robin M.;Myin Germeys, Inez;Mller Myhsok, Bertram;Nelis, Mari;Nenadic, Igor;Nertney, Deborah A.;Nestadt, Gerald;Nicodemus, Kristin K.;Nikitina Zake, Liene;Nisenbaum, Laura;Nordin, Annelie;O'Callaghan, Eadbhard;O'Dushlaine, Colm;O'Neill, F. Anthony;Oh, Sang Yun;Olincy, Ann;Olsen, Line;Van Os, Jim;Pantelis, Christos;Papadimitriou, George N.;Papiol, Sergi;Parkhomenko, Elena;Pato, Michele T.;Paunio, Tiina;Pejovic Milovancevic, Milica;Perkins, Diana O.;Pietilinen, Olli;Pimm, Jonathan;Pocklington, Andrew J.;Powell, John;Price, Alkes;Pulver, Ann E.;Purcell, Shaun M.;Quested, Digby;Rasmussen, Henrik B.;Reichenberg, Abraham;Reimers, Mark A.;Richards, Alexander L.;Roffman, Joshua L.;Roussos, Panos;Ruderfer, Douglas M.;Salomaa, Veikko;Sanders, Alan R.;Schall, Ulrich;Schubert, Christian R.;Schulze, Thomas G.;Schwab, Sibylle G.;Scolnick, Edward M.;Scott, Rodney J.;Seidman, Larry J.;Shi, Jianxin;Sigurdsson, Engilbert;Silagadze, Teimuraz;Silverman, Jeremy M.;Sim, Kang;Slominsky, Petr;Smoller, Jordan W.;So, Hon Cheong;Spencer, Chris C. A.;Stahl, Eli A.;Stefansson, Hreinn;Steinberg, Stacy;Stogmann, Elisabeth;Straub, Richard E.;Strengman, Eric;Strohmaier, Jana;Stroup, T. Scott;Subramaniam, Mythily;Suvisaari, Jaana;Svrakic, Dragan M.;Szatkiewicz, Jin P.;Sderman, Erik;Thirumalai, Srinivas;Toncheva, Draga;Tooney, Paul A.;Tosato, Sarah;Veijola, Juha;Waddington, John;Walsh, Dermot;Wang, Dai;Wang, Qiang;Webb, Bradley T.;Weiser, Mark;Wildenauer, Dieter B.;Williams, Nigel M.;Williams, Stephanie;Witt, Stephanie H.;Wolen, Aaron R.;Wong, Emily H. M.;Wormley, Brandon K.;Wu, Jing Qin;Xi, Hualin Simon;Zai, Clement C.;Zheng, Xuebin;Zimprich, Fritz;Wray, Naomi R.;Stefansson, Kari;Visscher, Peter M.;Adolfsson, Rolf;Andreassen, Ole A.;Blackwood, Douglas H. R.;Bramon, Elvira;Buxbaum, Joseph D.;Børglum, Anders D.;Cichon, Sven;Darvasi, Ariel;Domenici, Enrico;Ehrenreich, Hannelore;Esko, Tonu;Gejman, Pablo V.;Gill, Michael;Gurling, Hugh;Hultman, Christina M.;Iwata, Nakao;Jablensky, Assen V.;Jonsson, Erik G.;Kendler, Kenneth S.;Kirov, George;Knight, Jo;Lencz, Todd;Levinson, Douglas F.;Li, Qingqin S.;Liu, Jianjun;Malhotra, Anil K.;Mccarroll, Steven A.;Mcquillin, Andrew;Moran, Jennifer L.;Mortensen, Preben B.;Mowry, Bryan J.;Nthen, Markus M.;Ophoff, Roel A.;Owen, Michael J.;Palotie, Aarno;Pato, Carlos N.;Petryshen, Tracey L.;Posthuma, Danielle;Rietschel, Marcella;Riley, Brien P.;Rujescu, Dan;Sham, Pak C.;Sklar, Pamela;David, S.t. Clair;Weinberger, Daniel R.;Wendland, Jens R.;Werge, Thomas;Daly, Mark J.;Sullivan, Patrick F.;O'Donovan, Michael C.;Kraft, Peter;Hunter, David J.;Adank, Muriel;Ahsan, Habibul;Aittomäki, Kristiina;Baglietto, Laura;Berndt, Sonja;Blomquist, Carl;Canzian, Federico;Chang Claude, Jenny;Chanock, Stephen J.;Crisponi, Laura;Czene, Kamila;Dahmen, Norbert;Dos Santos Silva, Isabel;Easton, Douglas;Eliassen, A. Heather;Figueroa, Jonine;Fletcher, Olivia;Garcia Closas, Montserrat;Gaudet, Mia M.;Gibson, Lorna;Haiman, Christopher A.;Hall, Per;Hazra, Aditi;Hein, Rebecca;Henderson, Brian E.;Hofman, Albert;Hopper, John L.;Irwanto, Astrid;Johansson, Mattias;Kaaks, Rudolf;Kibriya, Muhammad G.;Lichtner, Peter;Lindström, Sara;Liu, Jianjun;Lund, Eiliv;Makalic, Enes;Meindl, Alfons;Meijers Heijboer, Hanne;Müller Myhsok, Bertram;Muranen, Taru A.;Nevanlinna, Heli;Peeters, Petra H.;Peto, Julian;Prentice, Ross L.;Rahman, Nazneen;Sánchez, María José;Schmidt, Daniel F.;Schmutzler, Rita K.;Southey, Melissa C.;Tamimi, Rulla;Travis, Ruth;Turnbull, Clare;Uitterlinden, Andre G.;Van Der Luijt, Rob B.;Waisfisz, Quinten;Wang, Zhaoming;Whittemore, Alice S.;Yang, Rose;Zheng, Wei;Kathiresan, Sekar;Pato, Michele;Pato, Carlos;Tamimi, Rulla;Stahl, Eli;Zaitlen, Noah;Pasaniuc, Bogdan;Belbin, Gillian;Kenny, Eimear E.;Schierup, Mikkel H.;De Jager, Philip;Patsopoulos, Nikolaos A.;Mccarroll, Steve;Daly, Mark;Purcell, Shaun;Chasman, Daniel;Neale, Benjamin;Goddard, Michael;Visscher, Peter M.;Kraft, Peter;Patterson, Nick;Price, Alkes L.

2015-01-01