The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, APO866, has been previously shown to have antileukemic activity in preclinical models, but its cytotoxicity in primary leukemia cells is frequently limited. The success of current antileukemic treatments is reduced by the occurrence of multidrug resistance, which, in turn, is mediated by membrane transport proteins, such as P-glycoprotein-1 (Pgp). Here, we evaluated the antileukemic effects of APO866 in combination with Pgp inhibitors and studied the mechanisms underlying the interaction between these two types of agents.
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells / Cagnetta, Antonia; Caffa, Irene; Acharya, Chirag; Soncini, Debora; Acharya, Prakrati; Adamia, Sophia; Pierri, Ivana; Bergamaschi, Micaela; Garuti, Anna; Fraternali, Giulio; Mastracci, Luca; Provenzani, Alessandro; Zucal, Chiara; Damonte, Gianluca; Salis, Annalisa; Montecucco, Fabrizio; Patrone, Franco; Ballestrero, Alberto; Bruzzone, Santina; Gobbi, Marco; Nencioni, Alessio; Cea, Michele. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - STAMPA. - 2015 / 21:17(2015), pp. 3934-3945.
Titolo: | APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells |
Autori: | Cagnetta, Antonia; Caffa, Irene; Acharya, Chirag; Soncini, Debora; Acharya, Prakrati; Adamia, Sophia; Pierri, Ivana; Bergamaschi, Micaela; Garuti, Anna; Fraternali, Giulio; Mastracci, Luca; Provenzani, Alessandro; Zucal, Chiara; Damonte, Gianluca; Salis, Annalisa; Montecucco, Fabrizio; Patrone, Franco; Ballestrero, Alberto; Bruzzone, Santina; Gobbi, Marco; Nencioni, Alessio; Cea, Michele |
Autori Unitn: | |
Titolo del periodico: | CLINICAL CANCER RESEARCH |
Anno di pubblicazione: | 2015 |
Numero e parte del fascicolo: | 17 |
Codice identificativo Scopus: | 2-s2.0-84942885599 |
Codice identificativo Pubmed: | 25964294 |
Codice identificativo ISI: | WOS:000361910000017 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1158/1078-0432.CCR-14-3023 |
Handle: | http://hdl.handle.net/11572/111765 |
Citazione: | APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells / Cagnetta, Antonia; Caffa, Irene; Acharya, Chirag; Soncini, Debora; Acharya, Prakrati; Adamia, Sophia; Pierri, Ivana; Bergamaschi, Micaela; Garuti, Anna; Fraternali, Giulio; Mastracci, Luca; Provenzani, Alessandro; Zucal, Chiara; Damonte, Gianluca; Salis, Annalisa; Montecucco, Fabrizio; Patrone, Franco; Ballestrero, Alberto; Bruzzone, Santina; Gobbi, Marco; Nencioni, Alessio; Cea, Michele. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - STAMPA. - 2015 / 21:17(2015), pp. 3934-3945. |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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