Controlling neural stem cell division within the adult subventricular zone: an APPealing job.

For years, scientists investigating amyloid precursor protein (APP) have focused on its pathogenetic role in the brains of Alzheimer's disease patients. Now, a study by Caille et al. adds new sites of action and new physiological functions for APP. They show that there are binding sites for secreted N-terminal nonamyloidogenic APP (sAPP) on epidermal growth factor (EGF)-responsive neural stem cells in the subventricular zone of the adult brain, where sAPP acts as an EGF cofactor to stimulate proliferation of these cells. This result opens the hypothesis that changes in the levels of sAPP could influence activity of the neurogenic regions of the adult brain in normal and pathological conditions.



Titolo: Controlling neural stem cell division within the adult subventricular zone: an APPealing job.
Autori: Conti, Luciano; Cattaneo, E.
Autori Unitn: 
Conti, Luciano
mostra contributor esterni 
Titolo del periodico: TRENDS IN NEUROSCIENCES
Anno di pubblicazione: 2005
Numero e parte del fascicolo: 2
Codice identificativo Scopus: 2-s2.0-13144256746
Codice identificativo Pubmed: 15667924
Codice identificativo ISI: WOS:000227225600001
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.tins.2004.11.005
Handle: http://hdl.handle.net/11572/99143
Appare nelle tipologie:03.1 Articolo su rivista (Journal article)

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