NSC systems present unique opportunities that are starting to be successfully explored for genetic and chemical screening. These systems provide the possibility of identifying and optimizing molecules/drugs that could lead to the tighter control in self-renewal and lineage specification of NSCs as well as their functional maturation. This could be crucial in moving forward NSC-based therapies. It is expected that recent advances in the method of producing NSCs from patient-specific human induced pluripotent stem (iPS) cells and in the technologies to grow them in vitro, while preserving their full developmental potential, will allow a full exploitation of NSCs both in drug discovery programs and in predictive toxicology studies.
Titolo: | Neural stem cells as tools for drug discovery: novel platforms and approaches. |
Autori: | T., Gorba; Conti, Luciano |
Autori Unitn: | |
Titolo del periodico: | EXPERT OPINION ON DRUG DISCOVERY |
Anno di pubblicazione: | 2013 |
Numero e parte del fascicolo: | 9 |
Codice identificativo Scopus: | 2-s2.0-84883044632 |
Codice identificativo Pubmed: | 23725548 |
Codice identificativo ISI: | WOS:000323502200004 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1517/17460441.2013.805199 |
Handle: | http://hdl.handle.net/11572/99119 |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |