The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl--cyclodextrin (Me--CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C¼O stretching region, of complexes formed by Me--CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate
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Titolo: | Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R,S)-ibuprofen/methyl-β-cyclodextrin inclusion complexes | |
Autori: | V., Crupi; Guella, Graziano; D., Majolino; Mancini, Ines; A., Paciaroni; Rossi, Barbara; V., Venuti; Verrocchio, Paolo; Viliani, Gabriele | |
Autori Unitn: | ||
Titolo del periodico: | PHILOSOPHICAL MAGAZINE | |
Anno di pubblicazione: | 2011 | |
Codice identificativo Scopus: | 2-s2.0-79956126311 | |
Codice identificativo WOS: | WOS:000289513200003 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/14786435.2010.512575 | |
Handle: | http://hdl.handle.net/11572/97945 | |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |