The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl--cyclodextrin (Me--CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C¼O stretching region, of complexes formed by Me--CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate

Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R,S)-ibuprofen/methyl-β-cyclodextrin inclusion complexes

Guella, Graziano;Mancini, Ines;Rossi, Barbara;Verrocchio, Paolo;Viliani, Gabriele
2011-01-01

Abstract

The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl--cyclodextrin (Me--CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C¼O stretching region, of complexes formed by Me--CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate
2011
V., Crupi; Guella, Graziano; D., Majolino; Mancini, Ines; A., Paciaroni; Rossi, Barbara; V., Venuti; Verrocchio, Paolo; Viliani, Gabriele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/97945
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