Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4(+) T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals, Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses.
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Titolo: | Notch directly regulates Gata3 expression during T helper 2 cell differentiation. | |
Autori: | Terry C., Fang; Yumi Yashiro, Ohtani; Del Bianco, Cristina; Dawson M., Knoblock; Stephen C., Blacklow; Warren S., Pear | |
Autori Unitn: | ||
Titolo del periodico: | IMMUNITY | |
Anno di pubblicazione: | 2007 | |
Codice identificativo Pubmed: | 17658278 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.immuni.2007.04.018 | |
Handle: | http://hdl.handle.net/11572/96527 | |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |