Notch directly regulates Gata3 expression during T helper 2 cell differentiation.

Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4(+) T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals, Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses.

Titolo: Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
Autori: Terry C., Fang; Yumi Yashiro, Ohtani; Del Bianco, Cristina; Dawson M., Knoblock; Stephen C., Blacklow; Warren S., Pear
Autori Unitn: 
Del Bianco, Cristina
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Titolo del periodico: IMMUNITY
Anno di pubblicazione: 2007
Codice identificativo Pubmed: 17658278
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.immuni.2007.04.018
Handle: http://hdl.handle.net/11572/96527
Appare nelle tipologie:03.1 Articolo su rivista (Journal article)

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