In comparison with late-onset Alzheimer’s disease (LOAD, onset, >65 years), early-age-of-onset Alzheimer’s disease (EOAD, onset, <65 years) more often presents with language, visuospatial, and/or executive impairment, often occurring earlier than a progressive memory deficit. The logopenic variant of primary progressive aphasia (lv-PPA) and posterior cortical atrophy (PCA) have recently been described as possible atypical variants of EOAD. Lv-PPA is characterized by isolated language deficit, whereas PCA is characterized by predominant visuospatial deficits. Severe hemispheric gray matter (GM) atrophy associated with EOAD, lv-PPA, and PCA has been described, but regional patterns of white matter (WM) damage are still poorly understood.
Titolo: | White matter atrophy in Alzheimer's disease variants. |
Autori: | R., Migliaccio; F., Agosta; K. L., Possin; G. D., Rabinovici; B. L., Miller; Gorno Tempini, Maria Luisa |
Autori Unitn: | |
Titolo del periodico: | ALZHEIMER'S & DEMENTIA |
Anno di pubblicazione: | 2012 |
Numero e parte del fascicolo: | 5 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jalz.2012.04.010 |
Handle: | http://hdl.handle.net/11572/95503 |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |