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EnglishBETA-BINDERS form a recently developed extension of stochastic pi CALCULUS to describe micro-biological systems. It introduces special binders to wrap processes just as membranes enclose some living matter and hence to mimic biological interfaces. One means to define the operational semantics of a modeling formalism is by an abstract simulator description. In developing an abstract simulator for BETA-BINDERS concepts are adopted that have been developed in the context of JAMES II. Processors of the simulator are structured into a hierarchy and each of them is splitted into different methods. This design reflects the structure of BETA-BINDERS models and facilitates experimenting with different operational semantics. Two discrete event simulation schemes, the First-Gillespie method and Gibson-Bruck method, are combined to calculate the reactions that occur within and between the modeled bioprocesses, respectively. The functioning of the simulator is illustrated by processing step-wise the reaction of an immune cell to the occurrence of a virus.
| Titolo: | Developing An Hierarchical Simulator for Beta-binders |
| Autori: | J., Himmelspach; Lecca, Paola; Prandi, Davide; Priami, Corrado; Quaglia, Paola; A., Uhrmacher |
| Autori Unitn: | |
| Titolo del volume contenente il saggio: | Proc. 20th IEEE/ACM/SCS Workshop on Principles of Advanced and Distributed Simulation, PADS 2006, Singapore, May 24-26, 2006 |
| Luogo di edizione: | Los Alamitos |
| Casa editrice: | IEEE Computer Society |
| Anno di pubblicazione: | 2006 |
| ISBN: | 0769525873 |
| Handle: | http://hdl.handle.net/11572/94774 |
| Appare nelle tipologie: | 04.1 Saggio in atti di convegno (Paper in proceedings) |
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