We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functions that remains isolated for at least 2 years. Detailed speech and language evaluation was used to identify three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (SD; n = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10). Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. However, when each clinical variant was considered separately, distinctive patterns emerged: (1) NFPA, characterized by apraxia of speech and deficits in processing complex syntax, was associated with left inferior frontal and insular atrophy; (2) SD, characterized by fluent speech and semantic memory deficits, was associated with anterior temporal damage; and (3) LPA, characterized by slow speech and impaired syntactic comprehension and naming, showed atrophy in the left posterior temporal cortex and inferior parietal lobule. Apolipoprotein E ε4 haplotype frequency was 20% in NFPA, 0% in SD, and 67% in LPA. Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.

Cognition and anatomy in three variants of primary progressive aphasia / Gorno Tempini, Maria Luisa; Dronkers, Nf; Rankin, Kp; Ogar, Jm; Phengrasamy, L; Rosen, Hj; Johnson, Jk; Weiner, Mw; Miller, Bl. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - STAMPA. - 55:(2004), pp. 335-346. [10.1002/ana.10825]

Cognition and anatomy in three variants of primary progressive aphasia

Gorno Tempini, Maria Luisa;
2004-01-01

Abstract

We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functions that remains isolated for at least 2 years. Detailed speech and language evaluation was used to identify three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (SD; n = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10). Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. However, when each clinical variant was considered separately, distinctive patterns emerged: (1) NFPA, characterized by apraxia of speech and deficits in processing complex syntax, was associated with left inferior frontal and insular atrophy; (2) SD, characterized by fluent speech and semantic memory deficits, was associated with anterior temporal damage; and (3) LPA, characterized by slow speech and impaired syntactic comprehension and naming, showed atrophy in the left posterior temporal cortex and inferior parietal lobule. Apolipoprotein E ε4 haplotype frequency was 20% in NFPA, 0% in SD, and 67% in LPA. Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.
2004
Gorno Tempini, Maria Luisa; Dronkers, Nf; Rankin, Kp; Ogar, Jm; Phengrasamy, L; Rosen, Hj; Johnson, Jk; Weiner, Mw; Miller, Bl
Cognition and anatomy in three variants of primary progressive aphasia / Gorno Tempini, Maria Luisa; Dronkers, Nf; Rankin, Kp; Ogar, Jm; Phengrasamy, L; Rosen, Hj; Johnson, Jk; Weiner, Mw; Miller, Bl. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - STAMPA. - 55:(2004), pp. 335-346. [10.1002/ana.10825]
File in questo prodotto:
File Dimensione Formato  
GornoTempini_1.pdf

Solo gestori archivio

Tipologia: Post-print referato (Refereed author’s manuscript)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 885.92 kB
Formato Adobe PDF
885.92 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/91362
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1268
  • ???jsp.display-item.citation.isi??? 1101
  • OpenAlex ND
social impact