The anatomy and functional role of the inferior fronto-occipital fascicle (IFOF) remain poorly known. We accurately analyze its course and the anatomical distribution of its frontal terminations. We propose a classification of the IFOF in different subcomponents. Ten hemispheres (5 left, 5 right) were dissected with Klingler's technique. In addition to the IFOF dissection, we performed a 4-T diffusion tensor imaging study on a single healthy subject. We identified two layers of IFOF. The first one is superficial and antero-superiorly directed, terminating in the inferior frontal gyrus. The second is deeper and consists of three portions: posterior, middle and anterior. The posterior component terminates in the middle frontal gyrus (MFG) and dorso-lateral prefrontal cortex. The middle component terminates in the MFG and lateral orbito-frontal cortex. The anterior one is directed to the orbito-frontal cortex and frontal pole. In vivo tractography study confirmed these anatomical findings. We suggest that the distribution of IFOF fibers within the frontal lobe corresponds to a fine functional segmentation. IFOF can be considered as a "multi-function" bundle, with each anatomical subcomponent subserving different brain processing. The superficial layer and the posterior component of the deep layer, which connects the occipital extrastriate, temporo-basal and inferior frontal cortices, might subserve semantic processing. The middle component of the deep layer could play a role in a multimodal sensory-motor integration. Finally, the anterior component of the deep layer might be involved in emotional and behavioral aspects.
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Titolo: | Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. |
Autori: | Sarubbo, Silvio; A. D., Benedictis; I. L., Maldonado; Basso, Gianpaolo; H., Duffau |
Autori Unitn: | |
Titolo del periodico: | BRAIN STRUCTURE AND FUNCTION |
Anno di pubblicazione: | 2011 |
Codice identificativo Scopus: | 2-s2.0-80054105147 |
Codice identificativo Pubmed: | 22200882 |
Codice identificativo ISI: | WOS:000313019200002 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00429-011-0372-3 |
Handle: | http://hdl.handle.net/11572/90102 |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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Sarubbo -FrontalTermiationsofIFOF-HumanStructFunct 2011.pdf | Abstract | Tutti i diritti riservati (All rights reserved) | Administrator |