Fatty acid composition of common barbel ( Barbusbarbus) roe and evaluation of its haemolytic  and cytotoxic activities

Imancini, I.Mancini; Defant, A.; Mesaric, T.; Potocnik, F.; Batista, U.; Guella, G.; Turk, T.; Sepcic, K.

doi:10.1016/j.toxicon.2011.04.004

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Eggs of the common barbel (Barbus barbus) cause intoxication in humans after ingestion. In this work, the chemical composition of the haemolytically active fraction from methanolic barbel roe extract was analyzed. Compounds showing haemolytic activity and cytotoxicity towards normal and transformed cell lines were isolated and identified as polyunsaturated fatty acids, using online liquid chromatography–electrospray ionization mass spectrometry through tandem fragmentation experiments (HPLC–MS/MS). Arachidonic acid (C20:4), docosahexaenoic acid (C22:6) and eicosapentaenoic acid (C20:5) proved to be the three most abundant members of a complex series of free fatty acids ranging from C14:0 to C24:5.

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/88117

Titolo:	Fatty acid composition of common barbel ( Barbusbarbus) roe and evaluation of its haemolytic and cytotoxic activities
Autori Unitn:	Mancini, Ines Defant, Andrea Guella, Graziano
Anno di pubblicazione:	2011
Titolo del periodico:	TOXICON
Abstract:	Eggs of the common barbel (Barbus barbus) cause intoxication in humans after ingestion. In this work, the chemical composition of the haemolytically active fraction from methanolic barbel roe extract was analyzed. Compounds showing haemolytic activity and cytotoxicity towards normal and transformed cell lines were isolated and identified as polyunsaturated fatty acids, using online liquid chromatography–electrospray ionization mass spectrometry through tandem fragmentation experiments (HPLC–MS/MS). Arachidonic acid (C20:4), docosahexaenoic acid (C22:6) and eicosapentaenoic acid (C20:5) proved to be the three most abundant members of a complex series of free fatty acids ranging from C14:0 to C24:5.
Handle:	http://hdl.handle.net/11572/88117
Appare nelle tipologie:	03.1 Articolo su rivista (Journal article)

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