Eggs of the common barbel (Barbus barbus) cause intoxication in humans after ingestion. In this work, the chemical composition of the haemolytically active fraction from methanolic barbel roe extract was analyzed. Compounds showing haemolytic activity and cytotoxicity towards normal and transformed cell lines were isolated and identified as polyunsaturated fatty acids, using online liquid chromatography–electrospray ionization mass spectrometry through tandem fragmentation experiments (HPLC–MS/MS). Arachidonic acid (C20:4), docosahexaenoic acid (C22:6) and eicosapentaenoic acid (C20:5) proved to be the three most abundant members of a complex series of free fatty acids ranging from C14:0 to C24:5.
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Titolo: | Fatty acid composition of common barbel ( Barbusbarbus) roe and evaluation of its haemolytic and cytotoxic activities | |
Autori: | Mancini, Ines; Defant, Andrea; T., Mesaric; F., Potocnik; U., Batista; Guella, Graziano; T., Turk; K., Sepcic | |
Autori Unitn: | ||
Titolo del periodico: | TOXICON | |
Anno di pubblicazione: | 2011 | |
Numero e parte del fascicolo: | 7 | |
Codice identificativo Scopus: | 2-s2.0-79956358041 | |
Codice identificativo Pubmed: | 21510968 | |
Codice identificativo WOS: | WOS:000291833400009 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.toxicon.2011.04.004 | |
Handle: | http://hdl.handle.net/11572/88117 | |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |