Silicon nanocrystals were made hydrophilic by 10-undecenoic acid grafting and were then coated with sodium deoxycholate, a detergent-like compound belonging to the bile acid class which is crucial for absorption of lipids in the small intestine. The resulting silicon nanocrystals have an average diameter of 3-5. nm, can be dispersed in aqueous solutions and show stable photoluminescence. Coating with non-biological surfactants, which are dangerous for cell safety, was investigated for comparison. Results indicate that deoxycholate is a stabilizer of luminescent silicon nanocrystals. Deoxycholate coated nanocrystals appear suitable for applications as multifunctional probes in biomedicine.

Deoxycholate as an efficient stabilizer of silicon nanocrystals.

Froner, Elena;D'Amato, Elvira;Adamo, Roberta;Larcheri, Silvia;Pavesi, Lorenzo;Scarpa, Marina
2011-01-01

Abstract

Silicon nanocrystals were made hydrophilic by 10-undecenoic acid grafting and were then coated with sodium deoxycholate, a detergent-like compound belonging to the bile acid class which is crucial for absorption of lipids in the small intestine. The resulting silicon nanocrystals have an average diameter of 3-5. nm, can be dispersed in aqueous solutions and show stable photoluminescence. Coating with non-biological surfactants, which are dangerous for cell safety, was investigated for comparison. Results indicate that deoxycholate is a stabilizer of luminescent silicon nanocrystals. Deoxycholate coated nanocrystals appear suitable for applications as multifunctional probes in biomedicine.
2011
Froner, Elena; D'Amato, Elvira; Adamo, Roberta; N., Prtlijaga; Larcheri, Silvia; Pavesi, Lorenzo; C., Potrich; A., Rigo; Scarpa, Marina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/86614
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