Semisynthetic derivatives of parthenolide (1) were tested on NF-kB driven transcription and metalloproteinase-9 (MMP-9) expression and secretion. The four membered ring compounds 5 and 6, obtained by acidic treatment of 1, exhibited a higher activity with respect to 1 in all the biological assays. Then an increased ability of the 5 and 6 to inhibit NF-kB driven transcription may lead to a down-regulation of MMP-9 expression and secretion. This work provides new details about the structural requisites for NF-kB inhibition.
Titolo: | Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives |
Autori: | Dell'Agli, M.; Galli, G. V.; Bosisio, E.; D'Ambrosio, Michele |
Autori Unitn: | |
Titolo del periodico: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
Anno di pubblicazione: | 2009 |
Codice identificativo Scopus: | 2-s2.0-61849170183 |
Codice identificativo ISI: | WOS:000264169700003 |
Handle: | http://hdl.handle.net/11572/86446 |
Appare nelle tipologie: | 03.1 Articolo su rivista (Journal article) |
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