Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge Echinochalina bargibanti collected from the northeastern coast of New Caledonia. In defining an adamantine-type polyarsenic structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin A; to this end, a comparative ab initio simulation of IR spectra for the natural and the synthetic compounds was decisive. Arsenicin A is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. All this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature.
|Titolo:||On the first polyarsenic organic compound from nature: Arsenicin A from the New Caledonian marine sponge Echinochalina bargibanti|
|Autori:||Mancini, Ines; Guella, Graziano; M., Frostin; E., Hnawia; D., Laurent; C., Debitus; F., Pietra|
|Titolo del periodico:||CHEMISTRY-A EUROPEAN JOURNAL|
|Anno di pubblicazione:||2006|
|Numero e parte del fascicolo:||35|
|Appare nelle tipologie:||03.1 Articolo su rivista (Journal article)|