Heart transplantation (HT) with grafts obtained by controlled donation after circulatory death (cDCD) has shown promising clinical results, with early and mid-term outcomes similar to donation after brain death (DBD) [1-2]. However, cDCD-HT success (both with direct organ procurement and thoraco-abdominal normothermic regional perfusion –taNRP–) has been demonstrated in countries with short asystolic ‘no-touch’ periods (e.g. five minutes for England or two minutes for Australia). Italy has one of the longest known no-touch periods for circulatory death declaration (twenty minutes), and this has been considered a major limiting factor for successful cDCD-HT. Nevertheless, cDCD- HT in Italy was approved in April 2023. Following approval from the Italian Regulatory Authority, the first cDCD-HT was performed in Padova on May 11th, 2023 [3].
Against Odds of Prolonged Warm Ischemia: Early Experience With DCD Heart Transplantation After 20-Minute No-Touch Period / Gerosa, G., Luciani, G.B., Pradegan, N., Tarzia, V., Lena, T., Zanatta, P., Pittarello, D., Onorati, F., Galeone, A., Gottin, L., Boffini, M., Zanierato, M., Marro, M., Martin Suarez, S., Botta, L., Lilla Della Monica, P., Feccia, M., Olivieri, G.M., Terzi, A., Oliveti, A., et al.. - In: CIRCULATION. - ISSN 0009-7322. - ELETTRONICO. - 150:17(2024), pp. 1391-1393. [10.1161/CIRCULATIONAHA.124.071239]
Against Odds of Prolonged Warm Ischemia: Early Experience With DCD Heart Transplantation After 20-Minute No-Touch Period
Onorati, Francesco;
2024-01-01
Abstract
Heart transplantation (HT) with grafts obtained by controlled donation after circulatory death (cDCD) has shown promising clinical results, with early and mid-term outcomes similar to donation after brain death (DBD) [1-2]. However, cDCD-HT success (both with direct organ procurement and thoraco-abdominal normothermic regional perfusion –taNRP–) has been demonstrated in countries with short asystolic ‘no-touch’ periods (e.g. five minutes for England or two minutes for Australia). Italy has one of the longest known no-touch periods for circulatory death declaration (twenty minutes), and this has been considered a major limiting factor for successful cDCD-HT. Nevertheless, cDCD- HT in Italy was approved in April 2023. Following approval from the Italian Regulatory Authority, the first cDCD-HT was performed in Padova on May 11th, 2023 [3].| File | Dimensione | Formato | |
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