The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie’s disease (PD) has been widely questioned. We aimed to determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD. This is the first study comparing sildenafil þ CCH vs CCH alone for the treatment of PD. Lack of randomization and direct verification of appropriate use of penile modeling could be considered limitations.
Sildenafil 25 mg ODT + Collagenase Clostridium hystoliticum vs Collagenase Clostridium hystoliticum Alone for the Management of Peyronie's Disease: A Matched-Pair Comparison Analysis / Cocci, Andrea; Cito, Gianmartin; Urzì, Daniele; Minervini, Andrea; Di Maida, Fabrizio; Sessa, Francesco; Mari, Andrea; Campi, Riccardo; Falcone, Marco; Capece, Marco; Morelli, Girolamo; Cacciamani, Giovanni; Rizzo, Michele; Polito, Chiara; Giammusso, Bruno; Morgia, Giuseppe; Verze, Paolo; Salonia, Andrea; Cai, Tommaso; Mirone, Vincenzo; Mondaini, Nicola; Russo, Giorgio Ivan. - In: JOURNAL OF SEXUAL MEDICINE. - ISSN 1743-6095. - STAMPA. - 15:10(2018), pp. 1472-1477. [10.1016/j.jsxm.2018.08.012]
Sildenafil 25 mg ODT + Collagenase Clostridium hystoliticum vs Collagenase Clostridium hystoliticum Alone for the Management of Peyronie's Disease: A Matched-Pair Comparison Analysis
Cai, Tommaso;
2018-01-01
Abstract
The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie’s disease (PD) has been widely questioned. We aimed to determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD. This is the first study comparing sildenafil þ CCH vs CCH alone for the treatment of PD. Lack of randomization and direct verification of appropriate use of penile modeling could be considered limitations.| File | Dimensione | Formato | |
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