This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study / Sideli, L., Aas, M., Quattrone, D., La Barbera, D., La Cascia, C., Ferraro, L., Alameda, L., Velthorst, E., Trotta, G., Tripoli, G., Schimmenti, A., Fontana, A., Gayer-Anderson, C., Stilo, S., Seminerio, F., Sartorio, C., Marrazzo, G., Lasalvia, A., Tosato, S., Tarricone, I., et al.. - In: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. - ISSN 0933-7954. - 58:10(2023), pp. 1573-1580. [10.1007/s00127-023-02513-0]

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Lasalvia, Antonio;
2023-01-01

Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
2023
10
Sideli, Lucia; Aas, Monica; Quattrone, Diego; La Barbera, Daniele; La Cascia, Caterina; Ferraro, Laura; Alameda, Luis; Velthorst, Eva; Trotta, Giulia;...espandi
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study / Sideli, L., Aas, M., Quattrone, D., La Barbera, D., La Cascia, C., Ferraro, L., Alameda, L., Velthorst, E., Trotta, G., Tripoli, G., Schimmenti, A., Fontana, A., Gayer-Anderson, C., Stilo, S., Seminerio, F., Sartorio, C., Marrazzo, G., Lasalvia, A., Tosato, S., Tarricone, I., et al.. - In: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. - ISSN 0933-7954. - 58:10(2023), pp. 1573-1580. [10.1007/s00127-023-02513-0]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/454097
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
  • OpenAlex 6
social impact