Aim: To assess the incidence and the temporal trend of type 1 diabetes (T1D) and diabetic ketoacidosis (DKA) during the period 2014–2023 in youths aged 0–14 years in the Trentino–Alto Adige region, Italy. Methods: A retrospective review of all incident cases of T1D diagnosed at the two Pediatric Diabetes Centers of Bolzano and Trento was matched with diabetes exemptions (No. 344). Demographic, clinical, and socioeconomic status (SES) data at first hospitalization were collected from subjects who agreed to participate (No. 272). Results: The incidence of T1D was 21.5/100,000 person/years, with a peak of 31.1 in 2021 during the COVID-19 pandemic. The mean age at the onset was 8.8 ± 3.9 years. Seventy-nine percent of the subjects were Italians, primarily residents in rural areas, and SES was equally represented. The mean incidence of DKA was 36.9%. The logistic regression analysis showed that the independent characteristics of the patients with DKA were of a younger age and displayed higher glycated hemoglobin (HbA1c) values. No relation of DKA with seasonality, ethnicity, or first-degree relative (FDR) with T1D or SES was detected. Conclusions: Our study revealed an incidence of T1D in the Trentino–Alto Adige region comparable to other areas in the North of Italy. The DKA rate negatively correlated with age; therefore, targeted prevention educational campaigns to increase awareness are needed.

Incidence of Type 1 Diabetes in Children Aged 0–14 Years in Trentino–Alto Adige Region and Determinants of Onset with Ketoacidosis / Fanti, Stefania; Lazzarotto, Denise; Reinstadler, Petra; Quaglia, Nadia; Maines, Evelina; Lamberti, Maria Agostina; Cauvin, Vittoria; Pertile, Riccardo; Soffiati, Massimo; Franceschi, Roberto. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 14:10(2024), pp. 105501-105510. [10.3390/jpm14101055]

Incidence of Type 1 Diabetes in Children Aged 0–14 Years in Trentino–Alto Adige Region and Determinants of Onset with Ketoacidosis

Pertile, Riccardo;Franceschi, Roberto
2024-01-01

Abstract

Aim: To assess the incidence and the temporal trend of type 1 diabetes (T1D) and diabetic ketoacidosis (DKA) during the period 2014–2023 in youths aged 0–14 years in the Trentino–Alto Adige region, Italy. Methods: A retrospective review of all incident cases of T1D diagnosed at the two Pediatric Diabetes Centers of Bolzano and Trento was matched with diabetes exemptions (No. 344). Demographic, clinical, and socioeconomic status (SES) data at first hospitalization were collected from subjects who agreed to participate (No. 272). Results: The incidence of T1D was 21.5/100,000 person/years, with a peak of 31.1 in 2021 during the COVID-19 pandemic. The mean age at the onset was 8.8 ± 3.9 years. Seventy-nine percent of the subjects were Italians, primarily residents in rural areas, and SES was equally represented. The mean incidence of DKA was 36.9%. The logistic regression analysis showed that the independent characteristics of the patients with DKA were of a younger age and displayed higher glycated hemoglobin (HbA1c) values. No relation of DKA with seasonality, ethnicity, or first-degree relative (FDR) with T1D or SES was detected. Conclusions: Our study revealed an incidence of T1D in the Trentino–Alto Adige region comparable to other areas in the North of Italy. The DKA rate negatively correlated with age; therefore, targeted prevention educational campaigns to increase awareness are needed.
2024
10
Fanti, Stefania; Lazzarotto, Denise; Reinstadler, Petra; Quaglia, Nadia; Maines, Evelina; Lamberti, Maria Agostina; Cauvin, Vittoria; Pertile, Riccard...espandi
Incidence of Type 1 Diabetes in Children Aged 0–14 Years in Trentino–Alto Adige Region and Determinants of Onset with Ketoacidosis / Fanti, Stefania; Lazzarotto, Denise; Reinstadler, Petra; Quaglia, Nadia; Maines, Evelina; Lamberti, Maria Agostina; Cauvin, Vittoria; Pertile, Riccardo; Soffiati, Massimo; Franceschi, Roberto. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 14:10(2024), pp. 105501-105510. [10.3390/jpm14101055]
File in questo prodotto:
File Dimensione Formato  
Fanti.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 398.92 kB
Formato Adobe PDF
398.92 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/452355
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
  • OpenAlex ND
social impact