Temporal lobe epilepsy is the most common focal epilepsy in adults and often causes pharmacoresistant seizures. Magnetic resonance imaging (MRI) and PET studies have widely demonstrated a number of morphological and molecular abnormalities in epilepsy. However, considering the dopaminergic system, only a bilateral 18F-DOPA uptake reduction within the basal ganglia has been described. We report the unusual finding of increased 18F- DOPA uptake in a patient with focal recurrent seizures and "deja vu" experiences in the setting of cortical swelling detected at MRI exam. The final diagnosis was in in keeping with hippocampal sclerosis, confirmed during follow-up MR exams. In this case 18F-DOPA uptake may represent increased dopamine transport induced by seizures. Nuclear medicine physicians and radiologists should be aware of clinical and electroencephalo- graphic findings when interpreting brain areas of tracer uptake, which are not always related to malignancy.
Unusual diagnostic findings in temporal lobe epilepsy: A combined MRI and 18F-dopa case study / Feraco, Paola; Donner, Davide; Picori, Lorena; Rozzanigo, Umberto. - In: EUROPEAN JOURNAL OF RADIOLOGY OPEN. - ISSN 2352-0477. - ELETTRONICO. - 7:(2020), pp. 1-3. [10.1016/j.ejro.2020.100241]
Unusual diagnostic findings in temporal lobe epilepsy: A combined MRI and 18F-dopa case study
Feraco, Paola
;
2020-01-01
Abstract
Temporal lobe epilepsy is the most common focal epilepsy in adults and often causes pharmacoresistant seizures. Magnetic resonance imaging (MRI) and PET studies have widely demonstrated a number of morphological and molecular abnormalities in epilepsy. However, considering the dopaminergic system, only a bilateral 18F-DOPA uptake reduction within the basal ganglia has been described. We report the unusual finding of increased 18F- DOPA uptake in a patient with focal recurrent seizures and "deja vu" experiences in the setting of cortical swelling detected at MRI exam. The final diagnosis was in in keeping with hippocampal sclerosis, confirmed during follow-up MR exams. In this case 18F-DOPA uptake may represent increased dopamine transport induced by seizures. Nuclear medicine physicians and radiologists should be aware of clinical and electroencephalo- graphic findings when interpreting brain areas of tracer uptake, which are not always related to malignancy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
