Background: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories. Methods: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4–6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. Results: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62–0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4–6.5 and ≥7, respectively. Conclusions: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.
Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories / Kaufmann, M.; Salmen, A.; Barin, L.; Puhan, M. A.; Calabrese, P.; Kamm, C. P.; Gobbi, C.; Kuhle, J.; Manjaly, Z. -M.; Ajdacic-Gross, V.; Schafroth, S.; Bottignole, B.; Ammann, S.; Zecca, C.; D'Souza, M.; von Wyl, V.. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 42:(2020), p. 102148. [10.1016/j.msard.2020.102148]
Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories
Barin L.;
2020-01-01
Abstract
Background: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories. Methods: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4–6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. Results: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62–0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4–6.5 and ≥7, respectively. Conclusions: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
