Abstract: In 2014, for the first time, visible hyperintensities on unenhanced T1-weighted images in the nucleus dentatus and globus pallidus of the brain were associated with previous Gadolinium-based contrast agent (GBCA) injections and gadolinium deposition in patients with normal renal function. This led to a frenzy of retrospective studies with varying methodologies that the European Society of Magnetic Resonance in Medicine and Biology Gadolinium Research and Educational Committee (ESMRMB-GREC) summarised in 2019. Now, after 10 years, the members of the ESMRMB-GREC look backward and forward and review the current state of knowledge of gadolinium retention and deposition. Clinical relevance statement: Gadolinium deposition is associated with the use of linear GBCA but no clinical symptoms have been associated with gadolinium deposition. Key Points : • Traces of Gadolinium-based contrast agent-derived gadolinium can be retained in multiple organs for a prolonged time. • Gadolinium deposition is associated with the use of linear Gadolinium-based contrast agents. • No clinical symptoms have been associated with gadolinium deposition.

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward / van der Molen, Aart J.; Quattrocchi, Carlo C.; Mallio, Carlo A.; Dekkers, Ilona A.. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - 34:1(2024), pp. 600-611. [10.1007/s00330-023-10281-3]

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

Quattrocchi, Carlo C.;
2024-01-01

Abstract

Abstract: In 2014, for the first time, visible hyperintensities on unenhanced T1-weighted images in the nucleus dentatus and globus pallidus of the brain were associated with previous Gadolinium-based contrast agent (GBCA) injections and gadolinium deposition in patients with normal renal function. This led to a frenzy of retrospective studies with varying methodologies that the European Society of Magnetic Resonance in Medicine and Biology Gadolinium Research and Educational Committee (ESMRMB-GREC) summarised in 2019. Now, after 10 years, the members of the ESMRMB-GREC look backward and forward and review the current state of knowledge of gadolinium retention and deposition. Clinical relevance statement: Gadolinium deposition is associated with the use of linear GBCA but no clinical symptoms have been associated with gadolinium deposition. Key Points : • Traces of Gadolinium-based contrast agent-derived gadolinium can be retained in multiple organs for a prolonged time. • Gadolinium deposition is associated with the use of linear Gadolinium-based contrast agents. • No clinical symptoms have been associated with gadolinium deposition.
2024
1
van der Molen, Aart J.; Quattrocchi, Carlo C.; Mallio, Carlo A.; Dekkers, Ilona A.
Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward / van der Molen, Aart J.; Quattrocchi, Carlo C.; Mallio, Carlo A.; Dekkers, Ilona A.. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - 34:1(2024), pp. 600-611. [10.1007/s00330-023-10281-3]
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