Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some N-methyl derivatives of agelastatin A. The study made use of chemical reactions and spectroscopic acquisitions. The chemical structure of some derivatives can undergo a profound rearrangement. The results could shed light on the mechanism of action of agelastatin A and suggest the preparation of analogues with improved pharmacological efficacy.

The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity / D’Ambrosio, Michele. - In: MOLECULES. - ISSN 1420-3049. - 28:19(2023), p. 6821. [10.3390/molecules28196821]

The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity

D’Ambrosio, Michele
2023-01-01

Abstract

Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some N-methyl derivatives of agelastatin A. The study made use of chemical reactions and spectroscopic acquisitions. The chemical structure of some derivatives can undergo a profound rearrangement. The results could shed light on the mechanism of action of agelastatin A and suggest the preparation of analogues with improved pharmacological efficacy.
2023
19
D’Ambrosio, Michele
The N-Alkylation of Agelastatin A Modulates Its Chemical Reactivity / D’Ambrosio, Michele. - In: MOLECULES. - ISSN 1420-3049. - 28:19(2023), p. 6821. [10.3390/molecules28196821]
File in questo prodotto:
File Dimensione Formato  
molecules-28-06821-with-cover.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 617.05 kB
Formato Adobe PDF
617.05 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/404509
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact