Stereotactic radiation therapy of liver metastases / Herfarth, Kk; Debus, J; Lohr, F; Bahner, Ml; Wannenmacher, M. - In: RADIOLOGE. - ISSN 0033-832X. - 41:1(2001), pp. 64-68. [10.1007/s001170050928]
Stereotactic radiation therapy of liver metastases
Lohr F;
2001-01-01
Abstract
Purpose. A number of minimal-invasive methods have been developed for the treatment of non-resectable liver metastases. A focused high dose can be delivered to a liver tumor with sparing of surrounding normal liver tissue using non-invasive stereotactic techniques. Methods. Sixty-six metastases were treated stereotactically in 43 patients during a phase 2 trial. Results. There were no major side effects observed. The actuarial local control was 82% after 18 months. The median actuarial survival was 24 months. However, there was a significantly improved survival in patients without additional extrahepatic tumor manifestation at the time of treatment compared to those, who were treated in palliative intention (87% vs. 24% after 18 months, p=0.001 (log-rank). Conclusion. Stereotactic single dose irradiation is a non-invasive and safe treatment option for patients with inoperable liver metastases. Phase III studies will further evaluate this new approach.File in questo prodotto:
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