Arterial hypertension, defined as an increase in systemic arterial pressure, is a major risk factor for the development of diseases affecting the cardiovascular system. Every year, 9.4 million deaths worldwide are caused by complications arising from hypertension. Despite well-established approaches to diagnosis and treatment, fewer than half of all hypertensive patients have adequately controlled blood pressure. In this scenario, computational models of hypertension can be a practical approach for better quantifying the role played by different components of the cardiovascular system in the determination of this condition. In the present work we adopt a global closed-loop multi-scale mathematical model for the entire human circulation to reproduce a hypertensive scenario. In particular, we modify the model to reproduce alterations in the cardiovascular system that are cause and/or consequence of the hypertensive state. The adaptation does not only affect large systemic arteries and the heart but also the microcirculation, the pulmonary circulation and the venous system. Model outputs for the hypertensive scenario are validated through assessment of computational results against current knowledge on the impact of hypertension on the cardiovascular system.

Modeling essential hypertension with a closed-loop mathematical model for the entire human circulation / Celant, Morena; Toro, Eleuterio F; Bertaglia, Giulia; Cozzio, Susanna; Caleffi, Valerio; Valiani, Alessandro; Blanco, Pablo J; Muller, Lucas Omar. - In: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING. - ISSN 2040-7939. - 39:11(2023), pp. e374801-e374836. [10.1002/cnm.3748]

Modeling essential hypertension with a closed-loop mathematical model for the entire human circulation

Celant, Morena;Toro, Eleuterio F;Cozzio, Susanna;Muller Lucas Omar
2023-01-01

Abstract

Arterial hypertension, defined as an increase in systemic arterial pressure, is a major risk factor for the development of diseases affecting the cardiovascular system. Every year, 9.4 million deaths worldwide are caused by complications arising from hypertension. Despite well-established approaches to diagnosis and treatment, fewer than half of all hypertensive patients have adequately controlled blood pressure. In this scenario, computational models of hypertension can be a practical approach for better quantifying the role played by different components of the cardiovascular system in the determination of this condition. In the present work we adopt a global closed-loop multi-scale mathematical model for the entire human circulation to reproduce a hypertensive scenario. In particular, we modify the model to reproduce alterations in the cardiovascular system that are cause and/or consequence of the hypertensive state. The adaptation does not only affect large systemic arteries and the heart but also the microcirculation, the pulmonary circulation and the venous system. Model outputs for the hypertensive scenario are validated through assessment of computational results against current knowledge on the impact of hypertension on the cardiovascular system.
2023
11
Celant, Morena; Toro, Eleuterio F; Bertaglia, Giulia; Cozzio, Susanna; Caleffi, Valerio; Valiani, Alessandro; Blanco, Pablo J; Muller, Lucas Omar...espandi
Modeling essential hypertension with a closed-loop mathematical model for the entire human circulation / Celant, Morena; Toro, Eleuterio F; Bertaglia, Giulia; Cozzio, Susanna; Caleffi, Valerio; Valiani, Alessandro; Blanco, Pablo J; Muller, Lucas Omar. - In: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING. - ISSN 2040-7939. - 39:11(2023), pp. e374801-e374836. [10.1002/cnm.3748]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/400092
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