We tested previous post-hoc findings indicating a relationship between functional connectivity (FC) in the motor network and corticospinal excitability (CsE), in a real-time EEG-TMS experiment in healthy participants. We hypothesized that high FC between left and right motor cortex predicts high CsE. FC was quantified in real-time by single-trial phase-locking value (stPLV), and TMS single pulses were delivered based on the current FC. CsE was indexed by motor-evoked potential (MEP) amplitude in a hand muscle. Possible confounding factors (pre-stimulus μ-power and phase, interstimulus interval) were evaluated post hoc. MEPs were significantly larger during high FC compared to low FC. Post hoc analysis revealed that the FC condition showed a significant interaction with μ-power in the stimulated hemisphere. Further, inter-stimulus interval (ISI) interacted with high vs. low FC conditions. In summary, FC was confirmed to be predictive of CsE, but should not be considered in isolation from μ-power and ISI. Moreover, FC was complementary to μ-phase in predicting CsE. Motor network FC is another marker of real-time accessible CsE beyond previously established markers, in particular phase and power of the μ rhythm, and may help define a more robust composite biomarker of high/low excitability states of human motor cortex.

Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG-TMS / Vetter, David Emanuel; Zrenner, Christoph; Belardinelli, Paolo; Mutanen, Tuomas Petteri; Kozák, Gábor; Marzetti, Laura; Ziemann, Ulf. - In: NEUROIMAGE. - ISSN 1095-9572. - 284:(2023), pp. 12042701-12042716. [10.1016/j.neuroimage.2023.120427]

Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG-TMS

Belardinelli, Paolo;Marzetti, Laura;
2023-01-01

Abstract

We tested previous post-hoc findings indicating a relationship between functional connectivity (FC) in the motor network and corticospinal excitability (CsE), in a real-time EEG-TMS experiment in healthy participants. We hypothesized that high FC between left and right motor cortex predicts high CsE. FC was quantified in real-time by single-trial phase-locking value (stPLV), and TMS single pulses were delivered based on the current FC. CsE was indexed by motor-evoked potential (MEP) amplitude in a hand muscle. Possible confounding factors (pre-stimulus μ-power and phase, interstimulus interval) were evaluated post hoc. MEPs were significantly larger during high FC compared to low FC. Post hoc analysis revealed that the FC condition showed a significant interaction with μ-power in the stimulated hemisphere. Further, inter-stimulus interval (ISI) interacted with high vs. low FC conditions. In summary, FC was confirmed to be predictive of CsE, but should not be considered in isolation from μ-power and ISI. Moreover, FC was complementary to μ-phase in predicting CsE. Motor network FC is another marker of real-time accessible CsE beyond previously established markers, in particular phase and power of the μ rhythm, and may help define a more robust composite biomarker of high/low excitability states of human motor cortex.
2023
Vetter, David Emanuel; Zrenner, Christoph; Belardinelli, Paolo; Mutanen, Tuomas Petteri; Kozák, Gábor; Marzetti, Laura; Ziemann, Ulf
Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG-TMS / Vetter, David Emanuel; Zrenner, Christoph; Belardinelli, Paolo; Mutanen, Tuomas Petteri; Kozák, Gábor; Marzetti, Laura; Ziemann, Ulf. - In: NEUROIMAGE. - ISSN 1095-9572. - 284:(2023), pp. 12042701-12042716. [10.1016/j.neuroimage.2023.120427]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/399792
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