The eikonal equation has become an indispensable tool for modeling cardiac electrical activation accurately and efficiently. In principle, by matching clinically recorded and eikonal-based electrocardiograms (ECGs), it is possible to build patient-specific models of cardiac electrophysiology in a purely non-invasive manner. Nonetheless, the fitting procedure remains a challenging task. The present study introduces a novel method, Geodesic- BP, to solve the inverse eikonal problem. Geodesic-BP is well-suited for GPU-accelerated machine learning frameworks, allowing us to optimize the parameters of the eikonal equation to reproduce a given ECG. We show that Geodesic-BP can reconstruct a simulated cardiac activation with high accuracy in a synthetic test case, even in the presence of modeling inaccuracies. Furthermore, we apply our algorithm to a publicly available dataset of a biventricular rabbit model, with promising results. Given the future shift towards personalized medicine, Geodesic-BP has the potential to help in future functionalizations of cardiac models meeting clinical time constraints while maintaining the physiological accuracy of state-ofthe- art cardiac models.

Digital twinning of cardiac electrophysiology models from the surface ECG: A geodesic backpropagation approach / Grandits, Thomas; Verhulsdonk, Jan; Haase, Gundolf; Effland, Alexander; Pezzuto, Simone. - In: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. - ISSN 0018-9294. - 71:4(2024), pp. 1281-1288. [10.1109/TBME.2023.3331876]

Digital twinning of cardiac electrophysiology models from the surface ECG: A geodesic backpropagation approach

Pezzuto, Simone
2024-01-01

Abstract

The eikonal equation has become an indispensable tool for modeling cardiac electrical activation accurately and efficiently. In principle, by matching clinically recorded and eikonal-based electrocardiograms (ECGs), it is possible to build patient-specific models of cardiac electrophysiology in a purely non-invasive manner. Nonetheless, the fitting procedure remains a challenging task. The present study introduces a novel method, Geodesic- BP, to solve the inverse eikonal problem. Geodesic-BP is well-suited for GPU-accelerated machine learning frameworks, allowing us to optimize the parameters of the eikonal equation to reproduce a given ECG. We show that Geodesic-BP can reconstruct a simulated cardiac activation with high accuracy in a synthetic test case, even in the presence of modeling inaccuracies. Furthermore, we apply our algorithm to a publicly available dataset of a biventricular rabbit model, with promising results. Given the future shift towards personalized medicine, Geodesic-BP has the potential to help in future functionalizations of cardiac models meeting clinical time constraints while maintaining the physiological accuracy of state-ofthe- art cardiac models.
2024
4
Grandits, Thomas; Verhulsdonk, Jan; Haase, Gundolf; Effland, Alexander; Pezzuto, Simone
Digital twinning of cardiac electrophysiology models from the surface ECG: A geodesic backpropagation approach / Grandits, Thomas; Verhulsdonk, Jan; Haase, Gundolf; Effland, Alexander; Pezzuto, Simone. - In: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. - ISSN 0018-9294. - 71:4(2024), pp. 1281-1288. [10.1109/TBME.2023.3331876]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/399171
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